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Abstract

A method of reducing the serum Lp(a) concentration in a subject is disclosed. A suspension of small, unilamellar vesicles composed primarily of phospholipids, similar in nature to those of egg phosphatidylcholine, is administered parenterally to a subject having or at risk for developing a disease condition associated with an elevated serum Lp(a) concentration. In the method, liposomes are infused over an extended period of time of at least several weeks, until a significant drop in serum Lp(a) concentration is observed.

Other References

• "Uptake of Endogenous Cholesterol by a Synthetic Lipoprotein"--1986 Elsev Science Publishers B.V. (Biomedical Division); Williams et al
• "Serum Lipoprotein (a) Levels Before and After Subtotal Thyroidectomy in Subjects With Hyperthyroidism"--Metabolism, vol. 44, No. 1 (Jan.), 1995: pp. 4-7; Yamamoto et al
• "The Relationship Between Serum Lipoprotein(a) and Restenosis After Initial Elective Percutaneous Transluminal Coronary Angioplasty"--Japanese Circulation Journal--vol. 57, Aug. 1993; Tenda et al
• "Perspectives in Biology and Medicine"--Perspectives in Biology and Medicine, 27, 3--Spring 1984; Williams et al
• "Low Levels of Serum Apolipoprotein A I and A II in Senile Dementia"--The Japanese Journal of Psychiatry and Neurology, vol. 48 No. 3, 1994; Kuriyama et al
• "Increased Concentrations of Serum Lp(a) Lipoprotein in Patients With Primary Gout"--Annals of the Rheumatic Diseases 1995; 54: 90-93; Takahashi et al
• "Elevated Serum Lp(a) Levels in the Early and Advanced Stages of Breast Cancer"--Cancer Biochem, Biophys., 1994, vol. 14, pp. 133-136; Kokoglu et al
• "Lipoprotein(a) in Type 1 Diabetic Patients with Renal Disease"--Original Articles--May 11, 1994; Groop et al
• "Prevention of Restenosis After Percutaneous Transluminal Coronary Angioplasty by Reducing Lipoprotein (a) Levels with Low-Density Lipoprotein Apheresis"--Jun. 1, 1994, vol. 73, No. 15; Daida et al
• Elevated Serum Lipoprotein(a) is a Risk Factor for Clinical Recurrence After Coronary Balloon Angioplasty--Circulation vol. 91, No. 5, Mar. 1, 1995; Desmarais et al.; Desmarais et a