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Inventors
Assignee
Application No. 453820 filed on 05/30/1995
US Classes: 424/45 ,
Organic pressurized fluid 424/46 Powder or dust containing
Examiners Primary:
Bawa, Raj
Attorney, Agent or Firm
Foreign Patent References 134923 DK. 02/13/1977 0 372 777 EP. 06/13/1990 A-0 372 777 EP. 06/13/1990 A-0 504 112 EP. 09/13/1992 0 504 112 EP. 09/13/1992 27 03 119 DE. 10/13/1990 437766 SE. 03/13/1985 86/04233 WO. 07/13/1986 A-86 04233 WO. 07/13/1986 90/07333 WO. 07/13/1990 91/04011 WO. 04/13/1991 91/11495 WO. 08/13/1991 91/11496 WO. 08/13/1991 91/11173 WO. 08/13/1991 91/14422 WO. 10/13/1991 92/00107 WO. 01/13/1992 92/06675 WO. 04/13/1992 92/08446 WO. 05/13/1992 92/08447 WO. 05/13/1992 A-92 08446 WO. 05/13/1992 92/11190 WO. 07/13/1992 92/22287 WO. 12/13/1992 92/22288 WO. 12/13/1992 93/11744 WO. 06/13/1993 93/11747 WO. 06/13/1993 93/11745 WO. 06/13/1993 93/11743 WO. 06/13/1993
International Class A61K 009/12
Foreign Application Priority Data 1991-12-12 GB
Abstract This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant and up to 5% w/w based upon propellant of a polar cosolvent, which formulation is substantially free of surfactant. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described.
Other References Oberholz, Frankfurter Allgemeine Zeitung, Oct. 1989, vol. 25, No. 207, p. 7 Dalby et al., Pharmaceutical Technology, Mar. 1990, vol. 14, No. 3, pp. 26-33 Amzacort™ carton, William H. Rorer, Inc., Fort Washington, Pennsylvania, USA 19034, 1986 Pharmaceutical Journal, Sep. 29, 1990, vol. 245, pp. 428-429, The Theory and Practice of Industrial Pharmacy, 2nd Ed., 1976 (Philadelphia, PA: Lea and Febiger), pp. 270 and 276-278 Handbook of Aerosol Technology, 2nd Edition, 1979 (New York, New York: Van Nostrand Reinhold Company), pp. 30, 32, 33, 166, 167, 232, 233 U.S. Senate Hearings, 12-14 May 1987, 343-347, 437 (U.S. Government Printing Office, Washington, D.C., 1987), CIS:1987-S321-26 Hagers Handbook of Pharmaceutical Practice, 1971, pp. 342-354 (Berlin: Spring-Verlag