U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Compositions of clindamycin and benzoyl peroxide for acne treatment

Patent 5733886 Issued on March 31, 1998. Estimated Expiration Date: Icon_subject March 31, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3535422

Composition and method for treatment of acne
Patent #: 3969516
Issued on: 07/13/1976
Inventor: Stoughton

Therapeutic composition
Patent #: 4056611
Issued on: 11/01/1977
Inventor: Young

Method for treating pseudofolliculitis barbae
Patent #: 4228163
Issued on: 10/14/1980
Inventor: Bliss

Method for treating acne vulgaris and compositions useful for that purpose
Patent #: 4318907
Issued on: 03/09/1982
Inventor: Kligman ,   et al.

Topical trien containing pharmaceutical compositions and methods of use
Patent #: 4323558
Issued on: 04/06/1982
Inventor: Nelson

Stable benzoyl peroxide composition
Patent #: 4387107
Issued on: 06/07/1983
Inventor: Klein ,   et al.

Topical medicament preparations
Patent #: 4411893
Issued on: 10/25/1983
Inventor: Johnson ,   et al.

Erythromycin/benzoyl peroxide composition for the treatment of acne
Patent #: 4497794
Issued on: 02/05/1985
Inventor: Klein ,   et al.

Method of treating acne vulgaris and composition
Patent #: 4505896
Issued on: 03/19/1985
Inventor: Bernstein

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Inventors

Assignee

Application

No. 235125 filed on 04/28/1994

US Classes:

514/24, S-glycoside514/714, Peroxide DOAI514/859Acne

Examiners

Primary: Peselev, Elli

Attorney, Agent or Firm

Foreign Patent References

  • 0413528 EP. 02/13/1991
  • 1594314 GB. 07/13/1981
  • 2088717 GB. 06/13/1982
  • 2150436 GB. 07/13/1985
  • WO 91/02533 WO. 03/13/1991

International Class

A61K 031/70

Abstract

Compositions suitable for the treatment of acne by topical application comprise clindamycin and benzoyl peroxide. Kits for preparing the compositions include a solution of clindamycin in a first container and a gel suspension of benzoyl peroxide in a second container. Each component is stored at a pH which promotes stability, and the combination of the two components provides a final composition having a pH which promotes stability and enhances viscosity.

Other References

  • S.B. Tucker et al, "Comparison of Topical Clindamycin Phosphate, Benzoyl Peroxide, and a Combination of the Two for the Treatment of Acne Vulgaris", British Journal of Dermatology (1984) 110, 487-492
  • Basotherm GmbH, Published Aug., 1991
  • Hirschmann (1988) Arch. Dermatol. 124:1691-1700
  • Fulton, Jr. et al. (1974) Arch. Dermatol. 110:83-8
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