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Stabilized pharmaceutical composition containing bupropion

Patent 5731000 Issued on March 24, 1998. Estimated Expiration Date: Icon_subject March 22, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventors

Assignee

Application

No. 586916 filed on 03/22/1996

US Classes:

424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/434, Mucosal (e.g., nasal, etc.)424/453, Telescoping two piece424/456, Gelatin424/457, Sustained or differential release424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/476, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof (e.g., chocolate)424/489Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)

Examiners

Primary: Page, Thurman K.
Assistant: Benston, William E. Jr.

Attorney, Agent or Firm

Foreign Patent References

  • 0 171 457 A1 EP. 02/13/1986
  • 0 467 488 A2 EP. 01/13/1992
  • 2 134 516 GB. 08/13/1984
  • WO 92/19226 WO. 11/13/1992
  • WO 94/04138 WO. 03/13/1994

International Class

A61K 009/48

Foreign Application Priority Data

1993-07-30 GB

Abstract

This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.

Other References

  • Walters, "Influence of pH on Hydrolytic Decomposition of Diethylopropion Hydrochloride: Stability Studies on Drug"-- J. of Phar. Sci. vol. 69, No. 10 (1980)
  • Laizure, et al. Ther. Drug Monit. 7(4): 447-450 (1985) "Stability of Bupropion" GA. 1040 814822 (1985)
  • Billinghurst, et al. GA 101:210748e (1985) of U.S. 2 134516 (Aug. 15, 1984)
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