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Electrode configuration for matrix addressing of a molecular detection device

Patent 5728532 Issued on March 17, 1998. Estimated Expiration Date: Icon_subject May 31, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method and device for moving molecules by the application of a plurality of electrical fields
Patent #: 5126022
Issued on: 06/30/1992
Inventor: Soane, et al.

Electrochemical denaturation of double-stranded nucleic acid
Patent #: 5527670
Issued on: 06/18/1996
Inventor: Stanley

Multi-site detection apparatus
Patent #: 5532128
Issued on: 07/02/1996
Inventor: Eggers, et al.

Active programmable electronic devices for molecular biological analysis and diagnostics Patent #: 5605662
Issued on: 02/25/1997
Inventor: Heller, et al.

Inventor

Application

No. 655797 filed on 05/31/1996

US Classes:

435/6, Involving nucleic acid422/50, ANALYZER, STRUCTURED INDICATOR, OR MANIPULATIVE LABORATORY DEVICE422/68.1, Means for analyzing liquid or solid sample422/81, Automated system with sample fluid pressure transport means422/82, And means segmenting fluid material435/5, Involving virus or bacteriophage435/7.1, Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate435/7.9, Assay in which an enzyme present is a label435/91.1, Polynucleotide (e.g., nucleic acid, oligonucleotide, etc.)435/91.5, Acellular preparation of polynucleotide435/292.1, Including means to transmit light into a bioreactor to facilitate photo- bioreaction (e.g., photosynthesis)435/299.1, Including solid extended fluid contact reaction surface435/808, OPTICAL SENSING APPARATUS435/814, ENZYME SEPARATION OR PURIFICATION436/182, ELEMENT OR INORGANIC COMPOUND436/501, BIOSPECIFIC LIGAND BINDING ASSAY436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/524, Carrier is inorganic436/525, Metal or metal coated436/528, Carrier is organic536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/24.32, Probes for detection of microbial nucleotide sequences536/24.33Primers

Examiners

Primary: Jones, W. Gary
Assistant: Rees, Dianne

International Classes

C12Q 001/68
C12P 019/34
G01N 033/53
G01N 015/06

Abstract

An apparatus and method for selectively attracting and inhibiting attraction of at least one predetermined molecule to a site in a molecular detection device utilizes a first electrode and a second electrode proximate to the site. The first electrode selectively generates a first electric field proximate to the site in response to a first signal applied thereto. The first electric field provides an attractive force to attract the at least one predetermined molecule toward the site. The second electrode selectively generates a second electric field proximate to the site in response to a second signal applied thereto. The second electric field selectively inhibits attraction of the at least one predetermined molecule toward the site by providing a repulsive force which dominates the attractive force provided by the first electric field.

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