17-aryl and 17-heterocyclyl-14ଲ-5-androstane, androstene and androstadiene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
Patent 5721227 Issued on February 24, 1998. Estimated Expiration Date: 
November 3, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 3, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References17-Aryl and 17-heterocyclyl-5ଲ,14ଲ-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same Patent #: 5567694 InventorsAssigneeApplicationNo. 552796 filed on 11/03/1995US Classes:514/172, Hetero ring containing514/176, Nitrogen containing hetero ring540/94, Hetero ring attached directly to the cyclopentanohydrophenanthrene ring system by nonionic bonding540/95, The hetero ring contains nitrogen540/101The hetero ring and acyclic chalcogen are both bonded directly at the 17 position of the cyclopentanohydrophenanthrene ring systemExaminersPrimary: Shah, Mukund J.Assistant: Kifle, Bruck Attorney, Agent or FirmInternational ClassesA61K 031/58C07J 043/00 C07J 017/00 Foreign Application Priority Data1992-09-29 DEAbstract17-Aryl -5,14ଲ-androstane, androstene and androstadiene derivatives of formula (I): ##STR1## wherein the symbol --- represents a single or a double bond; when the double bond is not present in the 4 or 5 position, the hydrogen in position 5 has the configuration;Y is oxygen or guanidinoimino, when --- in position 3 is a double bond;Y is hydroxy, OR2 or SR2, when in position 3 is a single bond and has an or ଲ configuration;R is a substituted or unsubstituted aryl ring; andR1 is hydrogen, methyl, ethyl or n-propyl substituted by OH or NR4 R5.Field of SearchHetero ring attached directly to the cyclopentanohydrophenanthrene ring system by nonionic bondingThe hetero ring contains nitrogen The hetero ring and acyclic chalcogen are both bonded directly at the 17 position of the cyclopentanohydrophenanthrene ring system Hetero ring containing Nitrogen containing hetero ring Oxygen double bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system Three or more oxygens bonded directly to the cyclopentanohydrophenanthrene ring system Two oxygens bonded directly to the cyclopentanohydrophenanthrene ring system |
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