U.S. patents available from 1976 to present.
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Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil

Patent 5719132 Issued on February 17, 1998. Estimated Expiration Date: Icon_subject June 27, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Synthesis of 1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) via direct fluorination
Patent #: 3948897
Issued on: 04/06/1976
Inventor: Townsend ,   et al.

Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
Patent #: 4328229
Issued on: 05/04/1982
Inventor: Fujii ,   et al.

Anti-cancer composition for delivering 5-fluorouracil
Patent #: 4507301
Issued on: 03/26/1985
Inventor: Fujii ,   et al.

Treatment of human viral infections
Patent #: 4724232
Issued on: 02/09/1988
Inventor: Rideout ,   et al.

Antiviral compositions and methods
Patent #: 4861759
Issued on: 08/29/1989
Inventor: Mitsuya ,   et al.

Treatment of cancer
Patent #: 4863902
Issued on: 09/05/1989
Inventor: Amagase ,   et al.

Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
Patent #: 4978655
Issued on: 12/18/1990
Inventor: Lin, et al.

5116823

Method of treating HIV in humans by administration of ddI and hydroxycarbamide
Patent #: 5521161
Issued on: 05/28/1996
Inventor: Malley, et al.

Compositions, methods and kits for potentiating antitumor effect and for treating tumor
Patent #: 5525603
Issued on: 06/11/1996
Inventor: Shirasaka, et al.

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Inventors

Assignee

Application

No. 671476 filed on 06/27/1996

US Classes:

514/50, 2,4-diketone pyrimidine or derivative (e.g., uracil, etc.)514/274, Chalcogen bonded directly to pyrimidine at 2-position536/28.55, Halogen bonded directly to the 5-position of the diazine ring (e.g., 5-fluorouridine, etc.)544/309, At 2-position and at 4- or 6-position544/310, Additional hetero ring which is unsaturated544/313Halogen attached directly to the diazine ring by nonionic bonding

Examiners

Primary: Kight, John
Assistant: Crane, L. Eric

Attorney, Agent or Firm

Foreign Patent References

  • 870982 BE. 02/13/1979
  • 4151988 JP. 11/13/1979
  • 58-38210 JP. 03/13/1983
  • 61-34428 JP. 08/13/1986
  • 136442 JP. 07/13/1989
  • 436237 JP. 02/13/1992
  • 848635 JP. 02/13/1996
  • 9117660 WO. 11/13/1991
  • WO93/01202 WO. 01/13/1993
  • 9301202 WO. 01/13/1993
  • 9426761 WO. 11/13/1994
  • WO94/27590 WO. 12/13/1994
  • 9512400 WO. 05/13/1995
  • 9628162 WO. 09/13/1996

International Classes

C07H 019/073
A01N 043/54
A61K 031/505
A61K 031/70

Abstract

The present invention is directed to the use of pharmaceutical compositions containing anti-retroviral effective amounts of (a) d4T and (b) 5-fluorouracil or a prodrug, or salt thereof.

Other References

  • S.D. Malley, et al, "Suppression of HIV Production in Resting Lymphocytes by Combining Didanosine and Hydroxamate Compounds," The Lancet, vol. 343, p. 1292, May 21, 1994
  • M.R. Posner, et al, "High-Dose Intravenous Zidovudine with 5-Fluorouracil and Leucovorin," Cancer, vol. 70, No. 12, pp. 2929-2934, Dec. 15, 1992
  • S.A. Riddler, et al, "Antiretroviral Activity of Stavudine (2',3'-Didehydro-3'-Deoxythymidine, D4T)," Antiviral Research, vol. 27, pp. 189-203, 1995
  • P.F. Lin, et al, "Genotypic and Phenotypic Analysis of Human Immunodeficiency Virus Type 1 Isolates from Patients on Prolonged Stavudine Therapy," J. Infect. Dis., vol. 170, pp. 1157-1164, 1994. (November)
  • W.-Y. Gao, et al, "Anti-Human Immunodeficiency Virus Type 1 Activity of Hydroxyurea in Combination with 2',3'-Dideoxynucleosides," Mol. Pharm., vol. 46, pp. 767-772, 1994
  • F. Lori, et al, "Hydroxyurea as an Inhibitor of Human Immunodeficiency Virus-Type 1 Replication," Science, vol. 266, pp. 801-805, (Nov. 4, 1994)
  • V.A. Johnson and R.E. Byington, "Quantitative Assays for Virus Infectivity," in A. Aldovini and B.D. Walker (Ed.), Techniques in HIV Research, Stockton Press, New York, pp. 71-76, 1990
  • S, Cox, et al, "Comparison of the Intracellular Metabolism of 3'-Azido-3'-Deoxythymidine and 3'-Fluoro-3'-Deoxythymidine in Lymphocytes in the Presence of 5-Fluoro-2'-Deoxyuridine," Antiviral Chemistry and Chemotherapy, vol. 1, No. 2, pp. 155-161, 1990
  • W.-Y. Gao, et al, "Low Levels of Deoxynucelotides in Peripheral Blood Lymphocytes: A Strategy to Inhibit Human Immunodeficiency Virus Type 1 Replication," Proc. Natl. Acad. Sci., vol. 90, pp. 8925-8928, Oct., 1993
  • J. Balzarini, et al, "2',3'-Dideoxycytidine: Regulation of its Metabolism and Anti-Retroviral Potency by Natural Pyrimidine Nucleogide Synthesis, and by Inhibitors of Pyrimidine Nucleotide Synthesis " Molecular Pharmacology, vol. 32, No. 6, pp. 798-806, Dec., 1987
  • M.N. Prichard, et al, "Inhibition of Thymidylate Synthase and Dihydrofolate Reductase Potentiate the Antiviral Effect of Acyclovir," Antiviral Research, vol. 20, pp. 249-259, 1993
  • F. Lori, et al, "Hydroxyurea Inhibits HIV-1 Replication by Inducing Low dNTP Levels. A Cellular Enzyme as a Target to Inhibit HIV-1," Antiviral Research, vol. 23, p. 63, 1994
  • W.-Y. Gao, et al, "Anti-HIV 1 Activity of Hydroxyurea in Combination with 2',3'-Dideoxynucleosides," Clinical Research, vol. 42, No. 2, p. 280A, 1994
  • Gong et al., "Potentiation of the Stavudine Anti-Human Immunodeficiency Virus Activity by 5-Fluorouracil," Antimicrobial Agents & Chemotherapy, 40(5), 1229 (May 1996)
  • Vila et al, "Absence of Viral Rebound After Treatment of HIV-Infected Patients with Didanosine ›ddI! and Hydroxycarbamide ›Hydroxyurea!," Lancet,350(9078), 635-636 (Aug. 30, 1997
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