U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Disposable package for use in aerosolized delivery of drugs

Patent 5718222 Issued on February 17, 1998. Estimated Expiration Date: Icon_subject May 30, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3187748

3565070

3658059

3812854

3814297

3826413

3861386

Respiratory biofeedback and performance evaluation system
Patent #: 3991304
Issued on: 11/09/1976
Inventor: Hillsman

Medical inhalation device for the treatment of diseases of the respiratory tract
Patent #: 4119096
Issued on: 10/10/1978
Inventor: Drews

Atomizer for fluids, preferably an inhalation device
Patent #: 4294407
Issued on: 10/13/1981
Inventor: Reichl ,   et al.

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Inventors

Assignee

Application

No. 454421 filed on 05/30/1995

US Classes:

128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/200.22, Gas flow induced by expansion chamber device (e.g., piston/cylinder ram, squeeze bulb, etc.)128/203.12Means for mixing treating agent with respiratory gas

Examiners

Primary: Lewis, Aaron J.

Attorney, Agent or Firm

Foreign Patent References

  • 0 186 280 EP. 10/13/1985
  • 0541127 EP. 05/13/1993
  • 0546607 EP. 06/13/1993
  • 81 21383 FR. 05/13/1983
  • 41 33 274 DE. 02/13/1993
  • 0530625 DE. 03/13/1993
  • 1 518 998 GB. 07/13/1978
  • 28 37 040 GB. 02/13/1980
  • 2055046 GB. 02/13/1981
  • 2 104 393 A GB. 03/13/1983
  • 2 255 918 GB. 11/13/1992
  • 2 256 805 B GB. 12/13/1992
  • WO 90/13327 WO. 11/13/1990
  • WO 91/14468 WO. 10/13/1991
  • WO 92/07599 WO. 05/13/1992
  • WO 92/09322 WO. 06/13/1992
  • WO 92/11050 WO. 07/13/1992
  • WO 93/03785 WO. 03/13/1993
  • WO 93/09832 WO. 05/13/1993
  • WO 93/17728 WO. 09/13/1993

International Class

A61M 011/00

Abstract

A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to and alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerosolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient.

Other References

  • Baum, E.A., et al., "A novel breath actuated piezo electronic inhaler" 3M Healthcare Product Bulletin, 3M House, Morley Street Loughborough. Leic S LE11 1EP, England (1 page total)
  • Byron, P.R., ed., Respiratory Drug Delivery CRC Press, Inc., Boca Raton, FL, (1990)
  • Newman et al., "Deposition of pressurised aerosols in the human respiratory tract" Thorax (1981) 36:52-55
  • Newman et al., "How should a pressurized ଲ-adrenergic bronchodilator be inhaled?" Eur.J. Respir. Dis. (1981) 62:3-21
  • Newman et al., "Deposition of pressurized suspension aerosols inhaled through extension devices 1-3 " Am. Rev. Respir. Dis. (1981) 124:317-320
  • Costar.RTM. Life Science Filtration Catalog, "Nucleopore.RTM.Polycarbonate Membranes" (1992) p.7
  • Harrison's Principles on Internal Medicine, "Diabetes Mellitus" (10th ed. 1983) 666-674
  • Newman et al., "Deposition of pressurised aerosols in the lung using radio-labelled particles" Thorax (1980) 35:23
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