Composition for applying active substances to or through the skin
Patent 5716638 Issued on February 10, 1998. Estimated Expiration Date: 
November 27, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 27, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMultiphase liposomal drug delivery system Method of preparing lipid structures Pro-liposome compositions Preparation of liposome and lipid complex compositions Pharmacological agent-lipid solution preparation Compositions for applying active substances to or through the skin Patent #: 5540934 InventorAssigneeApplicationNo. 563144 filed on 11/27/1995US Classes:424/450, Liposomes264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)424/63, LIVE SKIN COLORANT CONTAINING424/401Cosmetic, antiperspirant, dentifriceExaminersPrimary: Kishore, Gollamudi S.Attorney, Agent or FirmInternational ClassA61K 009/127AbstractA cosmetic or medical composition for topical application to the skin. It results in the transdermal passage of an active ingredient, or in the introduction of such agent into the skin. The essential components of such compositions are phospholipids, an aliphatic alcohol of three or four carbon atoms or a combination of these alcohols, water and a compatible active ingredient, optionally with propylene glycol. Compositions advantageously comprise from 0.5% to 10% phospholipids, from 5% to 35% of a C3 - or C4 -alcohol, 15 to 30% ethanol, which contain together at least 20% but not more than 40 wt. % of ethanol and the C3 -alcohol; up to 20 wt. % propylene glycol, at least 20% water and at least one active ingredient. The compositions are suitable for the topical application of a wide variety of cosmetic and pharmaceutically active compounds. Phospholipids of choice are phosphatidylcholine, (P C), hydrogenated P C, phosphatidic acid (P A), phosphatidylserine (P S), phosphatidylethanolamine (P E), phosphatidylglycerol (P P G) and phosphatidylinositol (P I).Other References
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