Hemodialysis method and membrane Patent #: 4925534
ApplicationNo. 284477 filed on 10/06/1994
US Classes:210/500.21, Semipermeable membrane210/500.22, Isotropically pored210/500.23, Hollow fiber or cylinder210/500.27, Organic210/500.3, Cellulose acetate210/500.35, Acrylate210/500.41, Sulfone210/500.43, Acrylonitrile210/646, Hemodialysis424/529, Blood530/380Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc.
ExaminersPrimary: Lilling, Herbert J.
Attorney, Agent or Firm
International ClassesA61M 001/16
Foreign Application Priority Data1992-04-12 JP
AbstractThe present invention relates to hematopoietic inhibiting factor-containing compositions which inhibit colony formation of CFU-E, comprising a substance obtained in the fraction eluting at exclusion limit by gel filtration using a gel having maximum molecular weight fractionation of not less than 200,000 and not more than 1,500,000, of a dialysate of blood which is obtained with a dialysis membrane having albumin sieving coefficient of not less than 0.01, followed by concentration with a membrane having molecular weight fractionation of not more than 5,000, and hematopoietic inhibiting factor-containing compositions which inhibit colony formation of CFU-E can be obtained. It further relates to a process of treating blood in which AI component is so removed as to satisfy AI/AAࣙ1/50, wherein AI is the height of the absorbancy value of the hematopoietic inhibiting factor-containing compositions and AA is the height of the maximum absorbancy value in a gel filtration pattern of solutes of the dialysate expressed in terms of the absorbancy at 280 nm, and to a dialysis membrane which satisfies AI/AAࣙ1/50. It further relates to drug compositions and a therapeutic agent for erythrocytosis, containing such hematopoietic inhibiting factor as the active ingredient.