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Methods for treating ulcerative colitis

Patent 5707622 Issued on January 13, 1998. Estimated Expiration Date: Icon_subject March 1, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Recombinant immunoglobin preparations Patent #: 4816567
Issued on: 03/28/1989
Inventor: Cabilly ,   et al.

Inventors

Application

No. 396851 filed on 03/01/1995

US Classes:

424/145.1, Binds hormone or other secreted growth regulatory factor, differentiation factor, or intercellular mediator (e.g., cytokine, etc.); or binds serum protein, plasma protein (e.g., tPA, etc.), or fibrin424/133.1, Structurally-modified antibody, immunoglobulin, or fragment thereof (e.g., chimeric, humanized, CDR-grafted, mutated, etc.)424/141.1, Monoclonal antibody or fragment thereof (i.e., produced by any cloning technology)424/158.1, Binds hormone or other secreted growth regulatory factor, differentiation factor, or intercellular mediator (e.g., cytokine, vascular permeability factor, etc.); or binds serum protein, plasma protein, fibrin, or enzyme530/387.3, Chimeric, mutated, or recombined hybrid (e.g., bifunctional, bispecific, rodent-human chimeric, single chain, rFv, immunoglobulin fusion protein, etc.)530/388.1, Monoclonal530/388.23Binds lymphokine, cytokine, or other secreted growth regulatory factor, differentiation factor, or intercellular mediator specific for a hematopoietic cell (e.g., interleukin, interferon, erythropoietin, etc.)

Examiners

Primary: Loring, Susan A.

Attorney, Agent or Firm

Foreign Patent References

  • 0 454 225 A1 EP 10/13/1991
  • 0 519 728 A2 EP 12/13/1992
  • 9109967 WO. 07/13/1991
  • WO 92/00327 WO 01/13/1992
  • WO 92/01054 WO 01/13/1992
  • WO 92/04372 WO 03/13/1992
  • WO 92/06697 WO 04/13/1992
  • WO 92/06196 WO 04/13/1992
  • WO 92/08474 WO 05/13/1992

International Classes

A61K 039/395
C07K 016/00
C07K 016/18
C07K 016/24

Abstract

Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.

Other References

  • Boylan et al., "Interleukin-8 is a major component of pleural liquid chemotactic activity in a rabbit model of endotoxin pleurisy" Amer. J. Physiol. 267(2):L137-L144 (1994)
  • Stockley, Robert A., "Role of Inflammation in Respiratory Tract Infections" Amer. J. Med. 99(Supp. 6B): 8S-13S (1995)
  • Raab, Y et al, Gut, 34:1203-1206, 1993
  • St. John, R.C. et al, Chest, 103:932-943, 1993
  • Boylan, A. Metal, J. Clin Invest, 89:1257-1267, Apr. 1992
  • Broaddus, V.C. et al, Am Rev. Respir. Dis, 146:825-830. 1992
  • Cross et al., "Choice of Bacteria in Animal Models of Sepsis" Inf. & Immunity 61(7) :2741-2747 (Jul. 1993)
  • Harris et al., "Therapeutic antibodies--the coming of age" Tibtech 11:42-44 (Feb. 1993)
  • Herbert et al., "Interleukin-8: A Review" Cancer Investigation 11(6) :743-750 (1993)
  • Ko et al., "A sensitive enzyme-linked immunosorbent assay for human interleukin-8" J. Immunol. Methods 149:227-235 (1992)
  • Mulligan et al., "Inhibition of Lung Inflammatory Reactions in Rats by an Anti-Human IL-8 Antibody" 150(12) :5585-5595 (Jun. 15, 1993)
  • Sartor, R. Balfour, "Animal Models of Intestinal Inflammation--Relevance to Inflammatory Bowel Disease", Inflammatory Bowel Disease (Chapter 18), McDermott et al., New York:Elsevier pp. 337-353 (1992)
  • Sekido et al., "Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8" Nature 365:654-657 (Oct. 14, 1993)
  • St. John et al., "Immunologic Therapy for ARDS, Septic Shock, and Multiple-Organ Failure" Chest 103:932-943 (1993)
  • Sticherling et al., "Immunohistochemical studies on NAP-1/IL-8 in contact eczema and atopic dermatitis" Arch. Dermatol. Res. 284:82-85 (1992)
  • Sticherling et al., "Production and Characterization of Monolclonal antibodies Against the Novel Neutrophil Activating Peptide NAP/IL-8" J. Immunol. 143(5) :1628-1634 (Sep. 1, 1989)
  • Wada et al., Jouranl of Experimental Medicine 180:1135-1140 (Sep. 1994)
  • Waldman, Thomas A., "Monoclonal Antibodies in Diagnosis and Therapy" Science 252:1657-1662 (Jun. 21, 1991)
  • Higa et al., "Attenuation of epithelial injury in acute experimental colitis by immunomodulators" Eur. Journal of Pharmacology 239:171-176 (1993)
  • Lichtiger et al., "Cyclosporine in severe ulcerative colitis refractory to steroid therapy" New England J. of Medicine 330(26) :1841-1845 (1994
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