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Prosaposin and cytokine-derived peptides

Patent 5700909 Issued on December 23, 1997. Estimated Expiration Date: Icon_subject December 23, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Application

No. 232513 filed on 04/21/1994

US Classes:

530/326, 15 to 23 amino acid residues in defined sequence530/32711 to 14 amino acid residues in defined sequence

Examiners

Primary: Allen, Marianne P.
Assistant: Hayes, Bret

Attorney, Agent or Firm

Foreign Patent References

  • 9311238 WO. 06/20/1993

International Class

C07K 014/52

Abstract

Prosaposin and peptide derivatives derived therefrom will promote neurite outgrowth in vitro. A peptide consensus sequence was determined by comparing the active neurite outgrowth-inducing saposin C peptide sequence with that of various hematopoietic and neuropoietic cytokines. These cytokine-derived peptides will promote the same processes as their corresponding cytokines. In addition, prosaposin and saposin C promote increased nerve cell myelination ex vivo.

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