Patent ReferencesOsmotic system for delivering selected beneficial agents having varying degrees of solubility Osmotic system with means for improving delivery kinetics of system Dispensing device with drug delivery patterns Dosage form comprising solubility regulating member Swelling modulated polymeric drug delivery device Enteric coated pharmaceutical compositions Multiparticulate pulsatile drug delivery system Patent #: 5260068 InventorApplicationNo. 424476 filed on 05/11/1995US Classes:604/892.1, Osmotic or diffusion pumped device or system424/473With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)ExaminersPrimary: Buiz, MichaelAssistant: Nguyen, Hiep T. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/22AbstractAn asymmetric membrane, osmotic, delivery device having coated macroparticulate solubility modifiers. The device comprises a beneficial agent, an osmagent, a coated macroparticulate solubility modifier and an asymmetric membrane that surrounds the device components. The device is useful for dispensing a beneficial agent to an aqueous environment of use. The coated macroparticles modify the solubility of the beneficial agent so that it's release can be controlled. The larger size of the solubility modifier macroparticles provides, for example, a longer release duration than would have been possible with a smaller size.Other References
Field of SearchImplanted dynamic device or systemCONTROLLED RELEASE THERAPEUTIC DEVICE OR SYSTEM Osmotic or diffusion pumped device or system Implant or insert Surgical implant or material Membrane or diffusion barrier Telescoping two piece Containing discrete coated particles pellets, granules, or beads Organic coatings Containing proteins or derivatives thereof (e.g., gelatin, etc.) Sustained or differential release type Discrete particles in supporting matrix Where particles are granulated Plural concentric cores Layered unitary dosage forms With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.) Gelatin Containing polysaccharide (e.g., cellulose sugars, etc.) Containing solid synthetic polymers Coated capsules Containing proteins or derivatives thereof Gelatin containing Containing polysaccharide (e.g., sugar, etc.) Containing solid synthetic polymers | |