U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease

Patent 5696109 Issued on December 9, 1997. Estimated Expiration Date: Icon_subject June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Antiviral compositions and method for their use
Patent #: 5106841
Issued on: 04/21/1992
Inventor: Scheer

Superoxide dismutase mimic
Patent #: 5223538
Issued on: 06/29/1993
Inventor: Fridovich, et al.

Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease Patent #: 5403834
Issued on: 04/04/1995
Inventor: Malfroy-Camine, et al.

Inventors

Assignee

Application

No. 485489 filed on 06/07/1995

US Classes:

514/185, Polycyclo ring system514/184, Heavy metal containing (including salts)514/492, Heavy metal containing DOAI514/501, Nickel or cobalt514/502, Iron514/505Cadmium or chromium

Examiners

Primary: Jarvis, William R. A.

Attorney, Agent or Firm

International Classes

A61K 031/555
A61K 031/28
A61K 031/295

Foreign Application Priority Data

1993-12-06 WO

Abstract

The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.

Other References

  • Boucher, "Synthesis and Spectroscopy of Chloro-Complexes of Some Derivatives of (Salicylaldehydeethylenediimato) Manganese(III)," J. Inorg. Nucl. Chem., 36:531-536 (1974)
  • Coleman, et al., "Characterization and Electrochemistry of Manganese(III) Complexes Containing Pentadentate Ligands," Inorg. Chem., 20:1253-1258 (1981)
  • Czapski and Goldstein, "Superoxide Scavengers and Sod or Sod Mimics," in Antioxidants in Therapy and Preventive Medicine, Eds. Emerit, et al., Plenum Press, New York, pp. 45-50 (1990)
  • de Garavilla, et al., "Novel Low-Molecular-Weight Superoxide Dismutase Mimic Deferoxamine-Manganese Improves Survival Following Hemorrhagic and Endotoxic Shock," Drug Development Research, 25:139-148 (1992)
  • Foye, "Radioprotective Drugs," in Burger's Medicinal Chemistry, Fourth Edition, Part III, pp. 11, 22, 29-35, 39, 44 (1981)
  • Fu, et al., "Mechanistic Study of a Synthetically Useful Monooxygenase Model Using the Hypersensitive Probe trans-2-Phenyl-1-vinylcyclopropane," J. Organic Chem., 113:6703-6704 (1991)
  • Jacobsen, National Science Foundation, Presidential Young Investigator Award, Grant No. CHE-9057740 (1990)
  • Jacobsen, National Institute of General Medical Sciences Notice of Grant Award, Grant No. 1 R01 GM 43214-01A1 (1991)
  • Jacobsen, et al., "Electronic Tuning of Asymmetric Catalysts," J. Organic Chem., 113:6703-6704 (1991)
  • Jacobsen, et al., "Highly Enantioselective Epoxidation Catalysts Derived from 1,2-Diaminocyclohexane," J. Amer. Chem. Soc., 113:7063-7064 (1991)
  • Kensler, et al., "Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase," Science, 221:75-77 (1983)
  • Kessel, et al., "Iron(III), Manganese(III), and Cobalt(III) Complexes with Single Chelating o-Semiquinone Ligands," Inorg. Chem., 19:1170-1178 (1980)
  • Lee, et al., "Enantiomerically Pure Epoxychromans via Asymmetric Catalysis," Tetrahedron Letters, 32(38):5055-5058 (1991)
  • Lee, et al., "Enantioselective Epoxidation of Conjugated Dienes and Enynes. Trans-Epoxides from Cis-Olefins," Tetrahedron Letters, 32(45):6533-6536 (1991)
  • Matsushita, et al., "The Preparation and Characterization of Dichloromanganese(IV) Schiff Base Complexes," Bull. Chem. Soc. Jpn., 54:2646-2651 (1981)
  • Matsushita, et al., "Reactions of Manganese(III) Schiff Base Complexes with Superoxide Ion in Dimethyl Sulfoxide," Bull. Chem. Soc. Jpn., 54:3743-3748 (1981)
  • Nagano, et al., "Superoxide Dismutase Mimics Based on Iron in Vivo," J. Biol. Chem., 264(16):9243-9249 (1989)
  • Pasini, et al., "Optically Active Complexes of Schiff Bases. Part 4. An Analysis of the Circular-dichroism Spectra of some Complexes of Different Co-ordination Numbers with Quadridentate Schiff Bases of Optically Active Diamines," J.C.S. Dalton, pp. 346-356 (1977)
  • Sittig, Handbook of Toxic and Hazardous Chemicals and Carcinogens, pp. 559-562, 639-641, 243-248 (1985)
  • Yamamoto, et al., "Anti-tumor promoting action of phthalic acidmono-n-butyl ester cupric salt, a biomimetic superoxide dismutase," Carcinogenesis, 11(5):749-754 (1990)
  • Zhang, et al., "Enantioselective Epoxidation of Unfunctionalized Olefins Catalyzed by (Salen)manganese Complexes," J. Am. Chem. Soc., 112:2801-2803 (1990)
  • Zhang, et al., "Asymmetric Olefin Epoxidation with Sodium Hypochlorite Catalyzed by Easily Prepared Chiral Mn(III) Salen Complexes," J. Am. Chem. Soc., 56:2296-2298 (1991
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
PatentsPlus: add to cart
PatentsPlus: add to cartIntelligent turbocharged patent PDFs with marked up images
$16.95more info
 
Sign InRegister
Username  
Password   
forgot password?