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Pharmaceutical composition containing botulinum B complex

Patent 5696077 Issued on December 9, 1997. Estimated Expiration Date: Icon_subject December 9, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method and device for pharmacological control of spasticity Patent #: 4932936
Issued on: 06/12/1990
Inventor: Dykstra, et al.

Inventors

Assignee

Application

No. 316820 filed on 10/03/1994

US Classes:

514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI424/184.1, ANTIGEN, EPITOPE, OR OTHER IMMUNOSPECIFIC IMMUNOEFFECTOR (E.G., IMMUNOSPECIFIC VACCINE, IMMUNOSPECIFIC STIMULATOR OF CELL-MEDIATED IMMUNITY, IMMUNOSPECIFIC TOLEROGEN, IMMUNOSPECIFIC IMMUNOSUPPRESSOR, ETC.)424/234.1, Bacterium or component thereof or substance produced by said bacterium (e.g., Legionella, Borrelia, Anaplasma, Shigella, etc.)424/247.1Clostridium (e.g., Clostridium tetani, Clostridium difficile, Clostridium perfringens, Clostridium botulinum, Clostridium chauvoei, etc.)

Examiners

Primary: Robinson, Douglas W.
Assistant: Wai, Thanda

Attorney, Agent or Firm

Foreign Patent References

  • 0068607 JP 06/20/1981
  • 2059970 GB 04/20/1981
  • WO 94/28922 WO. 12/20/1994
  • WO 94/28923 WO. 12/20/1994

International Classes

A61K 039/08
A61K 039/00
A61K 038/00
A61K 038/16

Abstract

A pharmaceutical preparation containing a complex consisting of type B botulinum neurotoxin and stabilizing proteins, both derived from C. botulinum, admixed with a pharmaceutically acceptable excipient is provided. The preparation is effective for inducing titratable, local, selective muscle denervation in a patient suffering from a disorder characterized by involuntary muscle spasm or contraction.

Other References

  • Schantz, E.J., et al., Journal of the Association of Official Analytical Chemists, vol. 61, pp. 96-99, Jan. 1978
  • Melling et al., Eye, vol. 2, pp. 16-23, 1988; "Clostridium Botulinum Toxins: Nature and Preparation for Clinical Use"
  • Kozaki et al., Infection and Immunity, vol. 10, pp. 750-756, 1974; "Purification and Some Properties of Progenitor Toxins . . . "
  • Borodic et al., Annals of Neurology, vol. 31, p. 113, Jan. 1992; "Treatment of Spasticity with Botulinum Toxin" (letter)
  • Schantz, E. J. et al., Microbiol. Rev., vol. 56, pp. 80-99, Mar. 1992; "Properties and Use of Botulinum Toxin . . . "
  • Schwarz, W., Arch. Lebensmittelhyg., vol. 30, pp. 29-33, 1979; (abstract); "Examinations on the stability.
  • Memin, B. et al., Rev. Neurol. (France), vol. 148, pp. 212-214, 1992; (abstract); "Effects on botulinum toxin on spasticity"
  • Saprykina, T.P. et al., Zh. Mikrobiol. Epidemiol. Immunobiol., vol. 57, pp. 86-91, 1980; (abstract); "Obtaining homogenous . . . "
  • Clarke, C.E., Q. J. Med., vol. 82, pp. 197-205, Mar. 1992; "Therapeutic Potential of Botulinum Toxin in Neurological . . . "
  • Jankovic, J. et al., New Eng. J. Med., vol. 324, pp. 1186-1194, 1991; "Therapeutic Uses of Botulinum Toxin"
  • Das, T.K. et al., Postgrad. Med. J., vol. 65, pp. 208-210, 1989; "Effect of treatment with botulinum toxin . . . "
  • Das, T.K. et al., Brit. J. Clin. Practice, vol. 43, pp. 401-403, 1989; "Botulinum toxin in treating spasticity"
  • Goodnough et al. Stabilization of botulinum toxin type A during lyophilization. Applied and Environmental Microbiology. 58(10):3426-3428, Oct. 1992
  • BOTOX in Physician's Desk Reference, Ed. David W. Sifton, Medical Economics Data Production Company, Montvale, New Jersey, 1994
  • Pikal, Michael J., "BioPharm", Freeze-Drying of Proteins Part II: Formulation Selection, 20-30 (Oct. 1990)
  • Evans et al., Eur. J. Biochem. 154, 409-416 (1986)
  • Patterson-Curtis et al., Applied & Environmental Microbiology, vol. 55, No. 6., Jun. 1989, pp. 1544-1548
  • Sellin et al., Acta Physiol Scand, vol. 119, 1983, pp. 127-133
  • Singh, et al., mOlecular and Cellular Biochemistry, vol., 1989 pp. 87-9
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