Pharmaceutical composition containing botulinum B complex
Patent 5696077 Issued on December 9, 1997. Estimated Expiration Date: December 9, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A pharmaceutical preparation containing a complex consisting of type B botulinum neurotoxin and stabilizing proteins, both derived from C. botulinum, admixed with a pharmaceutically acceptable excipient is provided. The preparation is effective for inducing titratable, local, selective muscle denervation in a patient suffering from a disorder characterized by involuntary muscle spasm or contraction.
Schantz, E.J., et al., Journal of the Association of Official Analytical Chemists, vol. 61, pp. 96-99, Jan. 1978
Melling et al., Eye, vol. 2, pp. 16-23, 1988; "Clostridium Botulinum Toxins: Nature and Preparation for Clinical Use"
Kozaki et al., Infection and Immunity, vol. 10, pp. 750-756, 1974; "Purification and Some Properties of Progenitor Toxins . . . "
Borodic et al., Annals of Neurology, vol. 31, p. 113, Jan. 1992; "Treatment of Spasticity with Botulinum Toxin" (letter)
Schantz, E. J. et al., Microbiol. Rev., vol. 56, pp. 80-99, Mar. 1992; "Properties and Use of Botulinum Toxin . . . "
Schwarz, W., Arch. Lebensmittelhyg., vol. 30, pp. 29-33, 1979; (abstract); "Examinations on the stability.
Memin, B. et al., Rev. Neurol. (France), vol. 148, pp. 212-214, 1992; (abstract); "Effects on botulinum toxin on spasticity"
Saprykina, T.P. et al., Zh. Mikrobiol. Epidemiol. Immunobiol., vol. 57, pp. 86-91, 1980; (abstract); "Obtaining homogenous . . . "
Clarke, C.E., Q. J. Med., vol. 82, pp. 197-205, Mar. 1992; "Therapeutic Potential of Botulinum Toxin in Neurological . . . "
Jankovic, J. et al., New Eng. J. Med., vol. 324, pp. 1186-1194, 1991; "Therapeutic Uses of Botulinum Toxin"
Das, T.K. et al., Postgrad. Med. J., vol. 65, pp. 208-210, 1989; "Effect of treatment with botulinum toxin . . . "
Das, T.K. et al., Brit. J. Clin. Practice, vol. 43, pp. 401-403, 1989; "Botulinum toxin in treating spasticity"
Goodnough et al. Stabilization of botulinum toxin type A during lyophilization. Applied and Environmental Microbiology. 58(10):3426-3428, Oct. 1992
BOTOX in Physician's Desk Reference, Ed. David W. Sifton, Medical Economics Data Production Company, Montvale, New Jersey, 1994
Pikal, Michael J., "BioPharm", Freeze-Drying of Proteins Part II: Formulation Selection, 20-30 (Oct. 1990)
Evans et al., Eur. J. Biochem. 154, 409-416 (1986)
Patterson-Curtis et al., Applied & Environmental Microbiology, vol. 55, No. 6., Jun. 1989, pp. 1544-1548
Sellin et al., Acta Physiol Scand, vol. 119, 1983, pp. 127-133
Singh, et al., mOlecular and Cellular Biochemistry, vol., 1989 pp. 87-9