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Method and system for use in treating a patient with immunosuppresants using whole blood level criteria to prevent an adverse immune response

Patent 5694950 Issued on December 9, 1997. Estimated Expiration Date: Icon_subject December 9, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Computer system and method for suggesting treatments for physical trauma
Patent #: 4839822
Issued on: 06/13/1989
Inventor: Dormond ,   et al.

Method for determining therapeutic drug dosage using bioelectrical resistance and reactance measurements
Patent #: 4880014
Issued on: 11/14/1989
Inventor: Zarowitz, et al.

Diabetes management system and apparatus
Patent #: 5019974
Issued on: 05/28/1991
Inventor: Beckers

Method for use in treating a patient with FK 506 to prevent an adverse immune response Patent #: 5365948
Issued on: 11/22/1994
Inventor: McMichael

Inventor

Assignee

Application

No. 291223 filed on 08/16/1994

US Classes:

128/898, Methods540/455Polycyclo ring system which contains the hetero ring as one of the cyclos

Examiners

Primary: Lacyk, John P.

Attorney, Agent or Firm

International Class

A61B 017/00

Abstract

A method and system for use in treating a patient with an immunosuppressant to prevent an adverse immune response, either a rejection of a transplanted organ or an attack on the patient's body by its own immune system caused by an autoimmune disease, without unduly suppressing the ability of the patient's immune system to combat infection. The method employs an expert system to provide non-numerical information concerning the course of action to be taken with respect to a patient's immunosuppressant treatment, at a given time, including, in particular, an instruction on whether the immunosuppressant dosage being administered to the patient should be changed, and if so how. That instruction is determined by the expert system through analysis of standardized characterizations assigned to standardized patient examination criteria including levels of the immunosuppressant in blood plasma and whole blood. The method also employs a means for determining the actual numerical immunosuppressant dosage the patient should receive at a given time.

Other References

  • Transplantation Proceedings, vol. XXIII, No. 6, Dec. 1991 (Appleton & Lange) (specifically, see the two articles below)
  • J. McMichael et al., Evaluation of a Novel "Intelligent" Dosing System for Optimizing FK 506 Therapy, Transplantation Proceedings, vol. XXIII No. 6, Dec. 1991, pp. 2780-2782
  • G.J.V. Nossal, Summary of the First International FK 506 Congress: Perspectives and Prospects, Transplantation Proceedings, vol. XXIII No. 6, Dec. 1991, pp. 3371-3375
  • Slides presented by John McMichael during a speech at the First International Congress on FK 506 on Aug. 21, 1991 at the University of Pittsburgh Medical Center (reported in the Transplantation Proceedings, vol. XXIII, No. 6, Dec. 1991)
  • Leslie Bendra Sabbagh, `Intelligent` Dosing System Optimizes Drug Therapy, The Medical Post. Sep. 17, 1991, p. 26 (The Medical Post is published in Toronto, Ontario, Canada)
  • Abbottbase™ Aminoglycosides Demonstration Program Operations Manual, Version 2.00 (and Software (not included)), by Abbott Diagnostics, Aug. 198
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