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Aryl group-or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-hiv agent

Patent 5688791 Issued on November 18, 1997. Estimated Expiration Date: Icon_subject September 11, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
Patent #: 4840956
Issued on: 06/20/1989
Inventor: Domagala ,   et al.

Antibacterially active pyrido-benzothiazine derivatives with long-term action
Patent #: 4868299
Issued on: 09/19/1989
Inventor: Fravolini ,   et al.

1-Cyclopropyl-6-fl uoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives
Patent #: 4880806
Issued on: 11/14/1989
Inventor: Ueda, et al.

7[4-(5 methyl-2-oxo-1,3-dioxalen-4-yl)methyl 1-piperzinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids
Patent #: 5086049
Issued on: 02/04/1992
Inventor: Kise, et al.

Antibacterial agents - II
Patent #: 5097032
Issued on: 03/17/1992
Inventor: Domagala, et al.

Piperazine derivatives
Patent #: 5210193
Issued on: 05/11/1993
Inventor: Sum, et al.

Quinolonecarboxylic acid derivatives and their use as antiviral agents
Patent #: 5217972
Issued on: 06/08/1993
Inventor: Grohe, et al.

Tricyclic compound or salts thereof, method for producing the same and antimicrobial agent containing the same Patent #: 5254685
Issued on: 10/19/1993
Inventor: Yokomoto, et al.

Inventors

Assignee

Application

No. 526225 filed on 09/11/1995

US Classes:

514/224.5, At least three cyclos in the polycyclo ring system514/230.2, Ring nitrogen shared by two of the cyclos514/250, At least three rings in the polycyclo ring system514/252.18, Additional six-membered hetero ring consisting of five ring carbons and one ring nitrogen attached directly or indirectly to the 1,3-diazine by nonionic bonding514/294, Ring nitrogen is shared by two of the cyclos514/934, Virus544/32, Tricyclo ring system having the six-membered hetero ring as one of the cyclos544/101, Tricyclo ring system having the oxazine ring as one of the cyclos544/344, Tricyclo ring system having the diazine ring as one of the cyclos544/361, The additional six-membered hetero ring is one of the cyclos in a polycyclo ring system546/80, Plural ring hetero atoms in the tricyclo ring system546/81, Plural ring nitrogens in the tricyclo ring system546/82, Three or more ring hetero atoms in the tricyclo ring system546/83, At least one of the ring hetero atoms is chalcogen546/84One of the cyclos is five-membered

Examiners

Primary: Grumbling, Matthew V.

Attorney, Agent or Firm

Foreign Patent References

  • 0 470 252 EP. 11/13/1990
  • 422 485 EP. 04/13/1991
  • 470 252 EP. 02/13/1992
  • WO 92/21659 WO. 12/13/1992

International Classes

A61K 031/54
A61K 031/535
C07D 401/02
C07D 403/02

Foreign Application Priority Data

1992-05-27 JP

Abstract

Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.

Other References

  • Chemical Abstracts, vol. 114, (1991), Abstract No. 247292, "Preparation of 4-oxo-3-quinolinecarboxylic acids and 4-oxo-1,8 naphthyridine-3-carboxylic acids as antiviral agents" of JP 02,264,724
  • R. Ruprecht et al., "Development of Antiviral Treatment Strategies in Murine Models", (1992), p. 997-1011, AIDS Research ad Human Retroviruses, 8(6)
  • Junko Nozaki-Renard et al., "A Fluoroquinolone (DR-3355) Protects Human Lymphocyte Cell Lines from HIV-1-induced Cytotoxicity", (1990), vol. 4, No. 1, pp. 1283-1286, AIDS
  • J. Benditt et al., "AIDS, the Unanswered Questions", Science, 260, 1253-1293, May 28, 1993
  • L. Elrod et al., "Determination of Minor Impurities in Temafloxacin Hydrochloride by High-Performance Liquid Chromatography", (1990), 125-136, Journal of Chromotography, 519 (1)
  • Rudi Pauwels et al., Journal of Virological Methods, 20, (1988), 309-321, "Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds"
  • Hayakawa et al., Chem. Pharm. Bull, (1984), 32(12), 4907-491
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