Method and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
Patent 5686289 Issued on November 11, 1997. Estimated Expiration Date: 
June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules Patent #: 5429938 InventorsApplicationNo. 487327 filed on 06/07/1995US Classes:435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE435/369, Renal origin or derivative435/377, Method of altering the differentiation state of the cell435/397, Support is a gel surface435/400, Hollow514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES530/399Hormones, e.g., prolactin, thymosin, growth factors, etc.ExaminersPrimary: Dodson, Shelley A.Attorney, Agent or FirmInternational ClassesA61K 038/18C12N 005/00 AbstractA novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Renal cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro. |
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