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US Patent 5686276 - Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism

US Patent Issued on November 11, 1997
Estimated Patent Expiration Date: Icon_subject May 12, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A process is provided for the bioconversion of a carbon substrate to 1,3-propanediol by a single organism utilizing either microorganisms containing the genes encoding for an active glycerol or diol dehydratase enzyme by contacting these organisms with a carbon substrate under the appropriate fermentation conditions.

Other References

  • Daniel, R. et al, J. of Bacteriology, 177(8), 2151-2156 (1995)
  • Tobimatsu, T. et al, J. Biolog. Chem., 270(13), 7142-7148 (1995)
  • Sobolov, M. et al, J. of Bacteriology, 79, 261-266 (1993)
  • Talarico, T.L. et al., Applied and Environmental Microbiology, Apr. 1990, pp. 943-948
  • Chemical Abstracts, vol. 118, No. 7, 15 Feb. 1993, Daniel, Rolf et al., "Growth Temperature-Dependent Activity of Glycerol Dehydratase in Escherichia coli Expressing the Citrobacter Freundii dha Regulon"
  • Chemical Abstracts, vol. 116, No. 9, 2 Mar. 1992, Tong, I Teh et al., "1,3-Propanediol Production by Escherichia coli Expressing Genes from the Klebsiella pneumoniae dha Regulon"
  • Chemical Abstracts, vol. 120, No. 11, 14 Mar. 1994, Otto, Karin Elizabeth, "Cloning and Characterization of the Propanediol Dehydratase Genes in Salmonella typhimurium"
  • Chemical Abstracts, vol. 118, No. 17, 26 Apr. 1993, Boenigk, Rainer et al., "Fermentation of Glycerol to 1,3-Propanediol in Continuous Cultures of Citrobacter freundii

Inventors

Assignee

Application

No. 440293 filed on 05/12/1995

US Classes:

435/158, Polyhydric435/252.31, Bacillus (e.g., B. subtilis, B. thuringiensis, etc.)435/252.33Escherichia (e.g., E. coli, etc.)

Field of Search

435/158, Polyhydric435/252.33, Escherichia (e.g., E. coli, etc.)435/252.31Bacillus (e.g., B. subtilis, B. thuringiensis, etc.)

Examiners

Primary: Lilling, Herbert J.

Foreign Patent References

  • 0 361 082 EP. 04/21/1990
  • 0 373 230 EP 06/21/1990
  • 3734 764 DE. 10/21/1987
  • 91 15590 WO. 10/21/1991
  • 93 25696 WO. 12/21/1993

International Classes

C12P 007/18
C12N 015/00
C12N 009/88
C12N 001/19

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