Method allowing sequential chemical reactions
Patent 5681751 Issued on October 28, 1997. Estimated Expiration Date: 
May 25, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 25, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAdsorption onto charcoal cloth Method for the sequential performance of chemical processes Method of sequencing peptides Methods for use in the mass analysis of chemical samples Thermal-assisted electrospray interface (TAESI) for LC/MS Electrophoretic antigen-antibody determination with laminate of multiple membranes Methods and apparatuses for preparative electrophoresis Method and apparatus for improved detection of ionic species by capillary electrophoresis Methods and apparatus allowing sequential chemical reactions Patent #: 5516698 InventorsApplicationNo. 450231 filed on 05/25/1995US Classes:436/89, Amino acid or sequencing procedure204/450, Electrophoresis or electro-osmosis processes and electrolyte compositions therefor when not provided for elsewhere204/451, Capillary electrophoresis436/180Volumetric liquid transferExaminersPrimary: Pyon, HaroldAttorney, Agent or FirmInternational ClassesG01N 027/30G01N 027/447 Foreign Application Priority Data1990-04-11 AUAbstractA first reactant is immobilized i.e. in a porous matrix (50), adjacent a sample electrode (46) within a reaction chamber. Energizing of the electrode (46) electrophoretically attracts a mobile second reactant and/or electrolytically induces appropriate reaction conditions to enhance reaction of the first and second reactants. Polarity reversals between the sample electrode (46) and remote electrodes (38), (42), (44) cause unreacted second reactant and/or by-products to migrate away from the immobilized first reactant. The techniques are useful for sequential chemical reactions such as sequencing or construction of proteins, polysaccharides and nucleic acids where cyclical additions and removals of reactants are required. The techniques are amenable to automated micro and nano scale construction and operation and allow direct electrophoretic (38) interfacing with chromatographic, HPCE and mass spectrophotometric equipment.Other References
Field of SearchElectrophoretic or electro-osmotic apparatusCapillary electrophoresis type Gel electrophoresis type Electrophoresis or electro-osmosis processes and electrolyte compositions therefor when not provided for elsewhere Capillary electrophoresis With detailed detection Solid sorption or desorption With addition of agent to facilitate removal Measuring electrical property Resistance or conductivity Including means for separating a constituent; e.g., filter, condenser, extractor, etc. Electrostatic field or electrical discharge With specific analytical program control means Amino acid or sequencing procedure MEASUREMENT OF ELECTRICAL OR MAGNETIC PROPERTY OR THERMAL CONDUCTIVITY Of a liquid INCLUDING CHROMATOGRAPHY NUCLEAR MAGNETIC RESONANCE, ELECTRON SPIN RESONANCE OR OTHER SPIN EFFECTS OR MASS SPECTROMETRY Liberation or purification of sample or separation of material from a sample (e.g., filtering, centrifuging, etc.) Including use of a solid sorbent, semipermeable membrane, or liquid extraction Volumetric liquid transfer |
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