U.S. patents available from 1976 to present.
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Intravascular stent and method

Patent 5679400 Issued on October 21, 1997. Estimated Expiration Date: Icon_subject June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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Prosthetic heart valve
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Inventor

Assignee

Application

No. 482346 filed on 06/07/1995

US Classes:

427/2.14, Particulate or unit-dosage-article base (e.g., tablet, pill, pellet, capsule, liposome, powder, controlled-release implant, suppository; excluding transdermal patch)427/2.24, Implantable permanent prosthesis (i.e., artificial body member) (e.g., pacemaker, lens, cornea, glaucoma shunt, heart valve, muscle, spinal disc, breast, internal organ)427/352Liquid extraction of coating constituent or cleaning coating

Examiners

Primary: Dudash, Diana

Attorney, Agent or Firm

Foreign Patent References

  • 9013332 WO. 11/21/1990
  • 9112779 WO. 09/21/1991
  • 9116102 WO. 10/21/1991
  • 9117789 WO. 11/21/1991
  • 9118940 WO. 12/21/1991
  • 9306792 WO. 04/21/1993
  • 0566245 WO. 10/21/1993

International Classes

B05D 003/00
B05D 001/38
A61J 003/00
A61L 027/00

Abstract

A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.

Other References

  • "Seeding of Intravascular Stents with Genetically Engineered Endothelial Cells" by Dicket et al, in Circulation, vol. 80, No. 5 Nov. 1989
  • "Restenosis and the Proportinal Neointimal Response to Coronary Artery Injury: Results in a Porcine Model" by Schwartz et al., in JACC, vol. 19, No. 2, Feb. 1992 pp. 267-274
  • "Restenosis After Baloon Angioplasty" by Schwartz, et al., in Circulation, vol. 82, No. 6, Dec. 199
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