Method of using IL-11 for treating spondyloarthropies

Patent 5679339 Issued on October 21, 1997. Estimated Expiration Date:

June 27, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventors

Application

No. 495724 filed on 06/27/1995

US Classes:

424/85.2, Interleukin530/351Lymphokines, e.g., interferons, interlukins, etc.

Examiners

Primary: Chan, Christina
Assistant: Nolan, Patrick J.

Attorney, Agent or Firm

Meinert; M. C.

Foreign Patent References

WO 91/07495 A1 WO. 05/13/1991
WO 94/05318 A1 WO. 03/13/1994
WO 95/24650 A2 WO. 09/13/1995

International Classes

A61K 045/05
C07K 017/00

Abstract

Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Clostridium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of minor metastases, asthma, preeclampsia, and allergic disorders such as rhinitis, conjunctivitis, and urticaria.

Other References

Feldmann et al., Annu. Rev. Immunol., 14:397-440, 1, 1996
Girasole et al., J. Clin. Invest., 93: 1516-1524, 5, 1994
Paul. In: Fundamental Immunology, Editor, William E. Paul, Publisher, Raven Press, 1, 1996, New York
Brennan, Clin. Exp. Immunol., 97: 1-3, 1, 1994
J.P. Leonard et al., J. Exp. Med 181:381-386 (1995)
R.H. Scofield et al., PNAS 90:9330-9334 (1993)
R.E. Hammer et al., Cell 63:1099-1112 (1990)
Sonis, et al., Proceedings of the American Assoc. for Cancer Research 36:368 (1995) (abstract 2190)
Keith, Jr. et al., Gastroenterology 108(4):A846 (1995) (abstract)
Keith, Jr. et al., Gastroenterology 106(4):A708 (1994) (abstract)
Keith, Jr. et al., Stem Cells 12(S1):79-90 (1994)
Opal, et al., Blood 86(10):498A (1995) (abstract)
Sonis, et al., European Journal of Cancer, Part B, Oral Oncology 31B(4):261-266 (1995