Patent ReferencesPiperazinyl derivatives of quinoline carboxylic acids 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them Benzoxazine derivatives Disinfectant solution for contact lens 7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds Patent #: 4670444 InventorsApplicationNo. 544624 filed on 10/18/1995US Classes:424/78.04, Ophthalmic preparation514/253.08, Having -C(=X)-, wherein X is chalcogen, bonded directly to carbon of the hetero ring of the quinoline ring system514/912OPHTHALMICExaminersPrimary: Fay, ZohrehAttorney, Agent or FirmInternational ClassA61K 031/74AbstractAqueous pharmaceutical compositions containing a synergistic combination of a quinolone and a polystyrene sulfonic acid polymer are described, wherein the compositions are clear solutions which are comfortable and have sustained release. Methods for use of the compositions are also disclosed. This type of formulation is particularly useful with ciprofloxacin-type quinolones by greatly increasing the solubility of these quinolones, making it feasible to have aqueous solutions containing such quinolones at or near physiological pH. | |