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Tumor necrosis factor antagonists and their use

Patent 5672347 Issued on September 30, 1997. Estimated Expiration Date: Icon_subject May 5, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Application

No. 435934 filed on 05/05/1995

US Classes:

424/139.1, Binds antigen or epitope whose amino acid sequence is disclosed in whole or in part (e.g., binds specifically-identified amino acid sequence, etc.)424/130.1, IMMUNOGLOBULIN, ANTISERUM, ANTIBODY, OR ANTIBODY FRAGMENT, EXCEPT CONJUGATE OR COMPLEX OF THE SAME WITH NONIMMUNOGLOBULIN MATERIAL424/141.1Monoclonal antibody or fragment thereof (i.e., produced by any cloning technology)

Examiners

Primary: Patterson, Charles L. Jr.

Attorney, Agent or Firm

International Class

A61K 039/395

Abstract

Tumor necrosis factor antagonists are administered in therapeutically effective doses to suppress inflammatory immune-potentiated events. The antagonists of this invention typically are selected from among several classes but preferably are neutralizing antibodies directed against tumor necrosis factor. The antagonists are useful in suppressing transplantation immunity and in the treatment of autoimmune diseases.

Other References

  • Beutler, B., et. al. (1986) Nature 320, 584-58
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