Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents

Patent 5670477 Issued on September 23, 1997. Estimated Expiration Date:

April 20, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3903262

Immunotherapy for AIDS patients
Patent #: 4863730
Issued on: 09/05/1989
Inventor: Karpas

Method to increase permeability of the blood-nerve/brain barriers to proteins Patent #: 5260308
Issued on: 11/09/1993
Inventor: Poduslo, et al.

Inventors

Assignee

Application

No. 425576 filed on 04/20/1995

US Classes:

514/2Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI

Examiners

Primary: MacMillan, Keith D.

Attorney, Agent or Firm

Schwegman, Lundberg, Woessner & Kluth, P.A.

International Class

A61K 023/02

Abstract

A method is provided to enhance the ability of a neurologically active compound to penetrate the blood nerve barrier (BNB) or blood brain barrier (BBB), by administration of a conjugate comprising the neurologically active compound linked to a carrier molecule that has been shown to have a substantial permeability coefficient across the BNB and BBB.

Other References

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