U.S. patents available from 1976 to present.
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Pyridinone thrombin inhibitors

Patent 5668289 Issued on September 16, 1997. Estimated Expiration Date: Icon_subject June 24, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Guanidine derivatives compositions and use
Patent #: 5260307
Issued on: 11/09/1993
Inventor: Ackermann, et al.

Sulfonamidocarboxamides Patent #: 5405854
Issued on: 04/11/1995
Inventor: Ackermann, et al.

Inventors

Assignee

Application

No. 669189 filed on 06/24/1996

US Classes:

546/293Sulfur bonded directly to acyclic nitrogen

Examiners

Primary: Ivy, C. Warren
Assistant: Aulakh, Charanjit S.

Attorney, Agent or Firm

Foreign Patent References

  • 0 509 769 A3 EP. 10/13/1992

International Classes

C07D 211/86
A61K 031/44

Abstract

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and have the following structure: ##STR1## for example: ##STR2##

Other References

  • Bernstein, et al., J. Med. Chem., 37, 3313-3326 "Nonpeptidic Inhibitors of Human Leukocyte Elastase . . . ", 199
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