Inhibition of aldosterone secretion
Cardiodilatin, a new peptide hormone and process for its preparation
Composition containing cordiodilatin or fragments thereof and methods of obtaining cardiodilatin
Method for determining cardiodilatin and fragments thereof and antibodies useful in determination of cardiodilatin and its fragments
Cardiodilatin fragment, process for preparing same and use thereof
Phosphorylated derivatives of cardiodilatin/ANF peptides Patent #: 5461142
ApplicationNo. 480359 filed on 06/07/1995
US Classes:530/334, Polymer supported synthesis, e.g., solid phase synthesis, Merrifield synthesis, etc.530/335, Protecting or removing protective groups, e.g., carboxyl group protection, etc.530/338, Solution phase synthesis530/339, Segment condensation, e.g., Ugi condensation, etc.530/344, Separation or purification530/834Urine; urinary system
ExaminersPrimary: Russel, Jeffrey E.
Attorney, Agent or Firm
Foreign Patent References
International ClassesC07K 001/02
Foreign Application Priority Data1987-03-02 DE
AbstractDescribed is a peptide fragment which comprises the amino acid sequence 95-126 of ANF/CDD 1-126 (gamma-hANaP) and is formed in the kidney. The fragment urodilatin (ANF/CDD 95-126) has the following amino acid sequence: ##STR1## wherein R1 and R2 each represent further peptide fragments of ANF/CDD 1-126 (gamma-hANaP). In the amino acid sequence R1 is Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser and R2 is Asn-Ser-Phe-Arg-Tyr. Further described are processes for the preparation and/or recovery of the new peptide fragment and a medicament containing urodilatin (ANF/CDD 95-126) as well as medical indications of the medicament.
Field of SearchPEPTIDE, PROTEIN OR AMINO ACID
25 or more peptide repeating units in known peptide chain structure
25 or more amino acid residues in defined sequence
Polymer supported synthesis, e.g., solid phase synthesis, Merrifield synthesis, etc.
Protecting or removing protective groups, e.g., carboxyl group protection, etc.
Solution phase synthesis
Segment condensation, e.g., Ugi condensation, etc.
Separation or purification
Urine; urinary system
Atrial or brain natriuretic peptide; related peptides