Biphenyl hydroxamate inhibitors of matrix metalloproteinases
Patent 5665777 Issued on September 9, 1997. Estimated Expiration Date: 
November 14, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 14, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3755603 Hydroxamic acid based collagenase inhibitors Aryl derivatives Patent #: 5036157 Inventors
ApplicationNo. 555690 filed on 11/14/1995US Classes:514/575, Hydroxamic acid or salt thereof558/411, Benzene ring bonded directly to the cyano group558/412, Sulfur and hydroxy bonded directly to the same benzene ring, or containing a monocyclic unsaturated alicyclic ring or thiocarbonyl558/414, Carbonyl attached indirectly to the cyano group by nonionic bonding562/621Hydroxamic acids, chalcogen analogs or salts thereof (i.e., compounds having the -C(=X)-N(R)-XH group or the -C(XH)=NXR group, wherein R may be hydrogen or substitution for hydrogen, the X's in each group may be the same or diverse chalcogens, and H of -XH in each group may be replaced by a group IA or IIA light metal, or by substituted or unsubstituted ammonium)ExaminersPrimary: Conrad, JosephAttorney, Agent or FirmForeign Patent References
International ClassesA61K 031/19C07C 255/00 C07C 259/08 AbstractCompounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF secretion.Other References
Field of SearchBenzene ring bonded directly to the cyano groupSulfur and hydroxy bonded directly to the same benzene ring, or containing a monocyclic unsaturated alicyclic ring or thiocarbonyl Carbonyl attached indirectly to the cyano group by nonionic bonding Hydroxamic acids, chalcogen analogs or salts thereof (i.e., compounds having the -C(=X)-N(R)-XH group or the -C(XH)=NXR group, wherein R may be hydrogen or substitution for hydrogen, the X's in each group may be the same or diverse chalcogens, and H of -XH in each group may be replaced by a group IA or IIA light metal, or by substituted or unsubstituted ammonium) Hydroxamic acid or salt thereof |
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