Process for preparing form 1 ranitidine hydrochloride
Patent 5663381 Issued on September 2, 1997. Estimated Expiration Date: 
April 21, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 21, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAminoalkyl furan derivatives Aminoalkyl furan derivative Process for forming Form 2 ranitidine hydrochloride Preparation of form 1 ranitidine hydrochloride Patent #: 5338871 InventorsAssigneeApplicationNo. 426930 filed on 04/21/1995US Classes:549/492Nitrogen and the hetero ring are single bonded directly to the same acyclic saturated hydrocarbon groupExaminersPrimary: Owens, AmeliaAttorney, Agent or FirmInternational ClassC07D 307/52AbstractA process for preparing pure N-[2-[[[5-[dimethylamino)-methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2- nitro-1,1-ethyldiamine hydrochloride, designated Form 1 ranitidine hydrochloride, from ranitidine in methylene chloride with the addition of hydrochloric acid. The Form 1 ranitidine hydrochloride thus obtained is stable and therefore useful for producing commercial-scale quantities of Form 1 ranitidine hydrochloride. |
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