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US Patent 5662932 - Solid fat nanoemulsions
US Patent Issued on September 2, 1997
Estimated Patent Expiration Date:
August 27, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
August 27, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractThe present invention provides pharmaceutical compositions comprising nanoemulsions of particles comprising a lipid core which is in a solid or liquid crystalline phase at 25° C., stabilized by at least one phospholipid envelope, for the parenteral, oral, intranasal, rectal, or topical delivery of both fat-soluble and water-soluble drugs. Particles have a mean diameter in the range of 10 to 250 nm. A wide variety of drugs and oxygen transporting perfluorocarbons may be encapsulated in the particles. In addition to drug delivery vehicles, the invention provides oxygen transporting blood substitutes, and nanoemulsions for extracorporeal maintenance of tissues prior to transplantation.Other References
| InventorsAssigneeApplicationNo. 697704 filed on 08/27/1996US Classes:424/450, Liposomes424/45, Organic pressurized fluid424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490, Coated (e.g., microcapsules)424/502, Contains waxes, higher fatty acids, higher fatty alcohols428/402.2, Microcapsule with fluid core (includes liposome)514/937DISPERSION OR EMULSIONField of Search424/450, Liposomes424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490, Coated (e.g., microcapsules)424/497, Containing solid synthetic polymers424/45, Organic pressurized fluid424/502, Contains waxes, higher fatty acids, higher fatty alcohols514/937, DISPERSION OR EMULSION514/938, Oil-water type514/939, Mineral oil-water type514/940, Quick break type514/941, Polyoxyalkylated compound containing514/942, Organic sulfonate, sulfate or sulfite containing514/943, Higher fatty acid or derivative containing428/402.2Microcapsule with fluid core (includes liposome)ExaminersPrimary: Kishore, Gollamudi S.Attorney, Agent or FirmUS Patent References5023271, Pharmaceutical microemulsionsIssued on: 06/11/1991 Inventor: Vigne, et al.5171737, Emulsions Issued on: 12/15/1992 Inventor: Weiner, et al.5188837, Lipsopheres for controlled delivery of substances Issued on: 02/23/1993 Inventor: Domb5284663, Salt film encapsulated perfluorocarbons Issued on: 02/08/1994 Inventor: Speaker5302401, Method to reduce particle size growth during lyophilization Issued on: 04/12/1994 Inventor: Liversidge, et al.5306508, Red blood cell surrogate Issued on: 04/26/1994 Inventor: Kossovsky, et al.5308624, Ophthalmic product Issued on: 05/03/1994 Inventor: Maincent, et al.5576016Solid fat nanoemulsions as drug delivery vehicles Issued on: 11/19/1996 Inventor: Amselem, et al. Foreign Patent References
International ClassesA61K 009/127A61K 009/16 |
