Benzodiazepine protein conjugates
Patent 5662911 Issued on September 2, 1997. Estimated Expiration Date: 
January 24, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 24, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDiazepam enzyme conjugates Complementation assay for drug screening Patent #: 5434052 InventorsAssigneeApplicationNo. 590830 filed on 01/24/1996US Classes:424/278.1, NONSPECIFIC IMMUNOEFFECTOR, PER SE (E.G., ADJUVANT, NONSPECIFIC IMMUNOSTI- MULATOR, NONSPECIFIC IMMUNOPOTENTIATOR, NONSPECIFIC IMMUNOSUPPRESSOR, NON- SPECIFIC IMMUNOMODULATOR, ETC.); OR NONSPECIFIC IMMUNOEFFECTOR, STABILIZER, EMULSIFIER, PRESERVATIVE, CARRIER, OR OTHER ADDITIVE FOR A COMPOSITION CON- TAINING AN IMMUNOGLOBULIN, AN ANTISERUM, AN ANTIBODY, OR FRAGMENT THEREOF, AN ANTIGEN, AN EPITOPE, OR OTHER IMMUNOSPECIFIC IMMUNOEFFECTOR514/686, Two benzene rings bonded directly to the same C=O530/402, Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.540/507, The additional chalcogen is bonded directly at the 3-position of the bicyclo ring system540/512, Chalcogen attached indirectly to nitrogen of the hetero ring by acyclic nonionic bonding540/514Nitrogen in the 1-position substituent of the bicyclo ring systemExaminersPrimary: Feisee, LilaAssistant: Ungar, Susan Attorney, Agent or FirmForeign Patent References
International ClassesA61K 045/00C07D 243/28 Foreign Application Priority Data1995-02-02 DEAbstractBenzodiazepine protein conjugates of the formula I ##STR1## wherein R1 is hydrogen, a methyl group or R, R2 is hydrogen, a hydroxyl or an OR group, with R1 or R2 containing an R group,R3 is a halogen, NO2 or NH2,X is hydrogen or a halogen,wherein R is a group of the formula II, wherein Z is a macromolecular immunogen reactive carrier substance and n is 2 or 3.The benzodiazepine protein conjugates are used as immunogens to obtain antibodies to benzodiazepines.The invention also relates to an immunoassay for the detection of benzodiazepines where the so generated antibodies are used.Other References
Field of SearchTwo benzene rings bonded directly to the same C=OChemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc. Nitrogen in the 1-position substituent of the bicyclo ring system Chalcogen attached indirectly to nitrogen of the hetero ring by acyclic nonionic bonding The additional chalcogen is bonded directly at the 3-position of the bicyclo ring system NONSPECIFIC IMMUNOEFFECTOR, PER SE (E.G., ADJUVANT, NONSPECIFIC IMMUNOSTI- MULATOR, NONSPECIFIC IMMUNOPOTENTIATOR, NONSPECIFIC IMMUNOSUPPRESSOR, NON- SPECIFIC IMMUNOMODULATOR, ETC.); OR NONSPECIFIC IMMUNOEFFECTOR, STABILIZER, EMULSIFIER, PRESERVATIVE, CARRIER, OR OTHER ADDITIVE FOR A COMPOSITION CON- TAINING AN IMMUNOGLOBULIN, AN ANTISERUM, AN ANTIBODY, OR FRAGMENT THEREOF, AN ANTIGEN, AN EPITOPE, OR OTHER IMMUNOSPECIFIC IMMUNOEFFECTOR |
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