Microprecipitation of micro-nanoparticulate pharmaceutical agents
January 10, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesInjectable compositions, nanoparticles useful therein, and process of manufacturing same Chemical compounds Triiodoisophthalamide X-ray contrast agent Process for the preparation of activated pharmaceutical compositions Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof Microdroplets of water-insoluble drugs and injectable formulations containing same Method for making uniformly sized particles from water-insoluble organic compounds Pharmaceutical vehicles for exhancing penetration and retention in the skin Methods of preparation of precipitated coupler dispersions with increased photographic activity 5118528 InventorsApplicationNo. 370936 filed on 01/10/1995US Classes:424/9.4, X-ray contrast imaging agent (e.g., computed tomography, angiography, etc.)424/9.5, Ultrasound contrast agent424/488, Polysaccharides (e.g., cellulose, etc.)424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490Coated (e.g., microcapsules)ExaminersPrimary: Hollinden, Gary E.Assistant: Hartley, Michael G. Attorney, Agent or FirmInternational ClassesA61K 009/14A61K 049/04 AbstractIt has been known that administration of pharmaceutical agents (both diagnostic and therapeutic) with poor water solubility in the form of particles less than 400 nm in diameter produces agent formulation with increased bioavailibility. Bioavailability being proportional to the surface area, increases with reduction of particle size of the dispersed agent. We have discovered that chemical derivatization of certain photographic coupler molecules with chemical moiety that are capable of functioning as pharmaceutical agents (both diagnostic and therapeutic) is amenable to the preparation of nanoparticulate pharmaceutical agent dispersions via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of a suitable surface-modifying, surface-active agent to form an ultra fine particle dispersion of the said pharmaceutical agent. The composition and process of this invention leads to particles of Z-average diameters as small as up to 10 nm as measured by photon correlation spectroscopy. The composition and process schemes of this invention are suitable for large-scale manufacture of these micro-nanoparticulate pharmaceutical agent dispersions.Other References
Field of SearchX-ray contrast imaging agent (e.g., computed tomography, angiography, etc.)Liposome containing Liposomes Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Contains proteins or derivative or polysaccharides or derivative Containing emulsions, dispersions, or solutions Polysaccharides (e.g., cellulose, etc.) Ultrasound contrast agent | |
