Monoclonal antibody

Patent 5658742 Issued on August 19, 1997. Estimated Expiration Date:

March 15, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventors

Assignee

Snow Brand Milk Products Co., Ltd.

Application

No. 404643 filed on 03/15/1995

US Classes:

435/7.9, Assay in which an enzyme present is a label435/7.21, Animal cell435/7.23, Tumor cell or cancer cell435/330, Immunoglobulin or antibody binds an expression product of a cancer related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.)435/331, Immunoglobulin or antibody binds a specifically identified amino acid sequence436/63, BIOLOGICAL CELLULAR MATERIAL TESTED436/64, CANCER530/387.7, Binds expression product of cancer-related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.)530/387.9, Binds specifically-identified amino acid sequence530/388.2, Binds microorganism or normal or mutant component or product thereof (e.g., animal cell, cell-surface antigen, secretory product, etc.)530/388.8Binds cancer cell or component or product thereof (e.g., cell-surface antigen, etc.)

Examiners

Primary: Reisee, Lila
Assistant: Eyler, Yvonne

Attorney, Agent or Firm

Testa, Hurwitz & Thibeault, LLP

Foreign Patent References

0519728 A2 EP 12/19/1992
0519728A2 EP 12/19/1992

International Classes

G01N 033/53
G01N 033/542
G01N 033/567
C07K 016/00

Foreign Application Priority Data

1994-03-18 JP

Abstract

This invention relates to a monoclonal antibody having affinity to human TCF-II without any affinity to HGF and determination or purification methods of TCF-II using the antibody. The monoclonal antibody can be obtained by adding a blocking solution containing a surface active agent to the culture medium containing monoclonal antibody to block antibodies other than said monoclonal antibody, followed by reaction with a solid phase antigen, TCF-II. Human TCF-II can be selectively and effectively purified or determined without any influence of the presence of HGF by using the antibody.

Other References

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