Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
Patent 5658583 Issued on August 19, 1997. Estimated Expiration Date: 
July 28, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 28, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3929131 Transdermal delivery of drugs Therapeutic system for administering drugs to the skin Local anesthetic mixture for topical application and method for obtaining local anesthesia Patch Two compartment mixing syringe Methods and instruments of moxibustion Temperature-controlled active agent dispenser Means for the application of transdermally absorbable active substances Monolithic user-activated transdermal therapeutic system InventorsApplicationNo. 508463 filed on 07/28/1995US Classes:424/402, Wearing apparel, fabric, or cloth424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/447, Bandages with incorporated medicaments424/448, Pressure sensitive adhesive means424/449, Transdermal or percutaneous514/817, ANESTHETIC, TOPICAL514/937, DISPERSION OR EMULSION514/944, GEL602/41, BANDAGE STRUCTURE602/46Polymeric foamExaminersPrimary: Phelan, D. GabrielleAttorney, Agent or FirmForeign Patent References
International ClassA01N 025/34AbstractAn apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.Other References
Field of SearchPressure sensitive adhesive meansTransdermal or percutaneous Wearing apparel, fabric, or cloth Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments Bandages with incorporated medicaments ANESTHETIC, TOPICAL DISPERSION OR EMULSION GEL BANDAGE STRUCTURE Polymeric foam | |
