Patent References 3800288 Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides Comparative molecular field analysis (COMFA) Knowledge-based molecular retrieval system and method using a hierarchy of molecular structures in the knowledge base Molecular dynamics simulation method and apparatus Method and apparatus for designing molecules with desired properties by evolving successive populations System and method of automatically generating chemical compounds with desired properties General strategy for vaccine and drug design Machine-learning approach to modeling biological activity for molecular design and to modeling other characteristics Patent #: 5526281 InventorsAssigneeApplicationNo. 422175 filed on 04/14/1995US Classes:703/11Biological or biochemicalExaminersPrimary: Teska, Kevin J.Assistant: Garbowski, Leigh Marie Attorney, Agent or FirmInternational ClassG06G 007/48AbstractA hierarchical biological modelling system and method provides integrated levels of information synthesized from multiple sources. An executable model of a biological system is developed from information and structures based on the multiple sources. The model is balanced to ensure that it matches the information and structures. Once the model is created and balanced it can be used to provide insight into phenomena at the cellular, or subcellular level, as well as phenomena at the patient, organ and system levels. From this information clinical trials can be emulated, biologic targets for drug development can be identified and subcellular phenomena over time can be observed. The model provides an integrated view of a multi-variable biological system. | |