Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
Patent 5652238 Issued on July 29, 1997. Estimated Expiration Date: 
May 9, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 9, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents 5'Indolinyl-5ଲ-amidomethyloxazolidin-2-ones Substituted 3(5'indazolyl) oxazolidin-2-ones Antibacterial 3-(fused-ring substituted)phenyl-5ଲ-amidomethyloxazolidin-2-ones 5547950 InventorsAssigneeApplicationNo. 640899 filed on 05/09/1996US Classes:514/235.8, Plural ring nitrogens in the additional hetero ring (e.g., imidazole, pyrazine, etc.)514/90, Chalcogen in the six-membered hetero ring514/252.11, Plural 1,4-diazine rings attached directly or indirectly to each other by nonionic bonding514/253.1, The five-membered nitrogen hetero ring has chalcogen as a ring member514/254.02, The additional five-membered hetero ring also has chalcogen as a ring member544/121, Piperazine ring544/337, Phosphorus attached directly or indirectly to the diazine ring by nonionic bonding544/357, Plural diazine rings544/364, At least three hetero rings containing544/367Ring chalcogen in the five-membered hetero ringExaminersPrimary: Ramsuer, Robert W.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/495A61K 031/535 C07D 413/10 C07D 413/14 AbstractA compound of structural Formula (I) or pharmaceutically acceptable salts thereof wherein: R is --C(O)--R1, --PO3 = or --P(O)(OH)2 ; R1 is C1-6 alkyl, --N(R4)2, C1-6 alkyl-N(R4)2, --phenyl--N(R4)2, --phenyl-NHC(O)CH2 NH2, --C2 H4 -morpholinyl, pyridinyl, C1-6 alkyl-OH, C1-6 alkyl-OCH3, C1-6 alkyl C(O)CH3, --O--C1-6 alkyl-OCH3, C0-3 alkyl-piperazinyl (optionally substituted with C1-3 alkyl), imidazolyl, C1-6 alkyl-COOH, --C(CH2 OH)2 CH3 ; R2 and R3 are independently selected from hydrogen or F except at least one of R2 or R3 is F; R4 are independently selected from hydrogen or C1-6 alkyl. The compounds are water soluble and are useful antimicrobial agents, effective against a number of human veterinary pathogens, including multiply-resistant staphylococci, enterococci and streptococci, as well as anerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis.Other References
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