Method of monitoring patient compliance with medications prescriptions
Patent 5652146 Issued on July 29, 1997. Estimated Expiration Date: 
July 5, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 5, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2564247 3856469 3901655 Radioimmunoassay for methadone Immunoassay for phencyclidine Method for the measurement of creatine or creatinine and reagents for these measurements Nitrogen test kit for physical training Method employing chemical markers and kit for verifying the source and completeness of urine samples for testing for the presence of drugs of abuse 5547878 InventorApplicationNo. 675863 filed on 07/05/1996US Classes:436/111, Amine and quaternary ammonium436/816, Alkaloids, amphetamines, and barbiturates436/901DRUGS OF ABUSE (E.G., NARCOTICS, AMPHETAMINE, ETC.)ExaminersPrimary: Alexander, Lyle A.Attorney, Agent or FirmInternational ClassG01N 033/48AbstractA method of monitoring compliance of a patient that has been placed on a medication maintenance program with a prescribed medication dosage by determining a normalized urine medication concentration. An unadulterated urine sample is obtained from the patient. The urine medication concentration and urine specific gravity are measured. The normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine and the urine specific gravity. The calculated normalized urine medication concentration is compared with an expected medication concentration value for the patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance. Alternatively, a urinary-parameter normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine, the urine specific gravity and at least one selected pharmacokinetic parameter of the medication. The calculated urinary-parameter normalized urine medication concentration is compared with an expected medication concentration value for an average compliant patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.Other References
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