Real time chemical exposure and risk monitor

Patent 5645072 Issued on July 8, 1997. Estimated Expiration Date:

September 28, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Re34938

3759249

3834375

Gaseous contaminate dosimeter and method
Patent #: 3985017
Issued on: 10/12/1976
Inventor: Goldsmith

Detecting method and apparatus using heat sensitive devices
Patent #: 4756670
Issued on: 07/12/1988
Inventor: Arai

Apparatus and method for analysis of expired breath
Patent #: 5042501
Issued on: 08/27/1991
Inventor: Kenny, et al.

Respiratory sampling device Patent #: 5111827
Issued on: 05/12/1992
Inventor: Rantala

Inventors

Application

No. 535929 filed on 09/28/1995

US Classes:

600/532, Qualitative or quantitative analysis of breath component600/538Measuring breath flow or lung capacity

Examiners

Primary: Cohen, Lee S.
Assistant: Huang, Stephen

Attorney, Agent or Firm

Zimmerman; Paul W.

International Class

A61B 005/09

Abstract

The apparatus of the present invention is a combination of a breath interface and an external exposure dosimeter interface to a chemical analysis device, all controlled by an electronic processor for quantitatively analyzing chemical analysis data from both the breath interface and the external exposure dosimeter for determining internal tissue dose. The method of the present invention is a combination of steps of measuring an external dose, measuring breath content, then analyzing the external dose and breath content and determining internal tissue dose.

Other References

Angela D. Arms, and Curtis C. Travis (U.S. Environmental Protection Agency); "Reference Physiological Parameters in Pharmacokinetic Modeling"; EPA Final Report #EPA/600/6-88/004; (Feb. 1988); pp. i through 7-16
PH Dawson, JB French, JA Buckley, DJ Douglas, and D. Simmons; "Mass Spectrometry, 1-The Instrument Parameters"; J. of Organic Mass Spectrometry, vol. 17, No. 5; (1982); pp. 205-211
PH Dawson, JB French, JA Buckley, DJ Douglas, D. Simmons; "The Use of Triple Quadrupoles for Sequential Mass Spectrometry, 2-A Detailed Case Study"; J. of Organic Mass Spectrometry, vol. 17, No. 5; (1982); pp. 212-219
James A. Bond, Lance A. Wallace, Siv Osterman-Golkar, George W. Lucier, Alan Buckpitt, and Rogene F. Hendersen; "Symposium Overview Assessment of Exposure to Pulmonary Toxicants: Use of Biological Markers"; J or Fundamental and Applied Toxicology, vol. 18; (1992); pp. 161-174
Dennis J. Paustenbach, Harvey J. Clewell III, Michael L. Gargas, and Melvin E. Andersen; "A Physiologically Based Pharmacokinetic Model for Inhaled Carbon Tetrachloride"; J. of Toxicology and Applied Pharmaclogy, vol. 96; (1988); pp. 191-211
Michael L. Gargas, Melvin E. Andersen and Harvey J. Clewell III; "A Physiologically Based Simulation Approach for Determining Metabolic Constants from Gas Uptake Data"; J. of Toxicology and Applied Pharmacology, vol. 86; (1986); pp. 341-352
John C. Ramsey and Melvin E. Andersen; "A Physiologically Description of the Inhalation Pharmacokinetics of Styrene in Rats and Humans"; J. of Toxicology and Applied Pharmacology, vol. 73; (1984); pp. 159-175
Michael L. Gargas, Harvey J. Clewell III, and Melvin E. Andersen; "Metabolism of Inhaled Dihalomethanes In Vivo: Differentiation of Kinetic Constants for Two Independent Pathways"; J. of Toxicology and Applied Pharmacology, vol. 82; (1986); pp. 211-223
Kent W. Thomas, Edo D. Pellizzari, and Stephen D. Cooper; "A Canister-Based Method for Collection and GC/MS Analysis of Volatile Organic Compounds in Human Breath"; J. of Analytical Toxicology, vol. 15; (Mar./Apr. 1991); pp. 54-59
JH Raymer, KW Thomas, SD Cooper, DA Whitaker, and ED Pellizzari; "A Device for Sampling of Human Alveolar Breath for the Measurement of Expired Volatile Organic Compounds"; J. of Analytical Toxicology, vol. 14; (Nov./Dec. 1990); pp. 337-34