AbstractThe apparatus of the present invention is a combination of a breath interface and an external exposure dosimeter interface to a chemical analysis device, all controlled by an electronic processor for quantitatively analyzing chemical analysis data from both the breath interface and the external exposure dosimeter for determining internal tissue dose. The method of the present invention is a combination of steps of measuring an external dose, measuring breath content, then analyzing the external dose and breath content and determining internal tissue dose. Other References- Angela D. Arms, and Curtis C. Travis (U.S. Environmental Protection Agency); "Reference Physiological Parameters in Pharmacokinetic Modeling"; EPA Final Report #EPA/600/6-88/004; (Feb. 1988); pp. i through 7-16
- PH Dawson, JB French, JA Buckley, DJ Douglas, and D. Simmons; "Mass Spectrometry, 1-The Instrument Parameters"; J. of Organic Mass Spectrometry, vol. 17, No. 5; (1982); pp. 205-211
- PH Dawson, JB French, JA Buckley, DJ Douglas, D. Simmons; "The Use of Triple Quadrupoles for Sequential Mass Spectrometry, 2-A Detailed Case Study"; J. of Organic Mass Spectrometry, vol. 17, No. 5; (1982); pp. 212-219
- James A. Bond, Lance A. Wallace, Siv Osterman-Golkar, George W. Lucier, Alan Buckpitt, and Rogene F. Hendersen; "Symposium Overview Assessment of Exposure to Pulmonary Toxicants: Use of Biological Markers"; J or Fundamental and Applied Toxicology, vol. 18; (1992); pp. 161-174
- Dennis J. Paustenbach, Harvey J. Clewell III, Michael L. Gargas, and Melvin E. Andersen; "A Physiologically Based Pharmacokinetic Model for Inhaled Carbon Tetrachloride"; J. of Toxicology and Applied Pharmaclogy, vol. 96; (1988); pp. 191-211
- Michael L. Gargas, Melvin E. Andersen and Harvey J. Clewell III; "A Physiologically Based Simulation Approach for Determining Metabolic Constants from Gas Uptake Data"; J. of Toxicology and Applied Pharmacology, vol. 86; (1986); pp. 341-352
- John C. Ramsey and Melvin E. Andersen; "A Physiologically Description of the Inhalation Pharmacokinetics of Styrene in Rats and Humans"; J. of Toxicology and Applied Pharmacology, vol. 73; (1984); pp. 159-175
- Michael L. Gargas, Harvey J. Clewell III, and Melvin E. Andersen; "Metabolism of Inhaled Dihalomethanes In Vivo: Differentiation of Kinetic Constants for Two Independent Pathways"; J. of Toxicology and Applied Pharmacology, vol. 82; (1986); pp. 211-223
- Kent W. Thomas, Edo D. Pellizzari, and Stephen D. Cooper; "A Canister-Based Method for Collection and GC/MS Analysis of Volatile Organic Compounds in Human Breath"; J. of Analytical Toxicology, vol. 15; (Mar./Apr. 1991); pp. 54-59
- JH Raymer, KW Thomas, SD Cooper, DA Whitaker, and ED Pellizzari; "A Device for Sampling of Human Alveolar Breath for the Measurement of Expired Volatile Organic Compounds"; J. of Analytical Toxicology, vol. 14; (Nov./Dec. 1990); pp. 337-34
| InventorsApplication No. 535929 filed on 09/28/1995 US Classes:600/532, Qualitative or quantitative analysis of breath component600/538Measuring breath flow or lung capacityField of Search128/204.17, Means for heating respiratory gas or respiration device128/206.21Face mask covering a breathing passageExaminers Primary: Cohen, Lee S. Assistant: Huang, StephenAttorney, Agent or FirmUS Patent References Re34938, 3759249, 3834375, 3985017, Gaseous contaminate dosimeter and method Issued on: 10/12/1976 Inventor: Goldsmith4756670, Detecting method and apparatus using heat sensitive devices Issued on: 07/12/1988 Inventor: Arai5042501, Apparatus and method for analysis of expired breath Issued on: 08/27/1991 Inventor: Kenny, et al.5111827Respiratory sampling device Issued on: 05/12/1992 Inventor: RantalaInternational Class A61B 005/09
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