U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Oral composition for the treatment of inflammatory bowel disease

Patent 5643602 Issued on July 1, 1997. Estimated Expiration Date: Icon_subject July 1, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Compositions and method of treating with stereoisomeric mixtures of 2-unsymmetrical 16,17-methylenedioxy steroids
Patent #: 3983233
Issued on: 09/28/1976
Inventor: Brattsand ,   et al.

Composition containing 5-sulfanilamido-3,4-dimethylisoxazole and a trimethoxybenzyl pyrimidine
Patent #: 3996356
Issued on: 12/07/1976
Inventor: Grunberg

Small particle formation and encapsulation
Patent #: 4606940
Issued on: 08/19/1986
Inventor: Frank ,   et al.

Minipellets
Patent #: 4708867
Issued on: 11/24/1987
Inventor: Hsiao

Prednisone microencapsulated granules Patent #: 4966770
Issued on: 10/30/1990
Inventor: Giannini, et al.

Inventor

Assignee

Application

No. 240078 filed on 05/09/1994

US Classes:

424/462, Containing solid synthetic polymers424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/494, Cellulose derivatives424/495, Ethyl cellulose424/497, Containing solid synthetic polymers514/925, ULCER TREATMENT514/951POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZE

Examiners

Primary: Webman, Edward J.

Attorney, Agent or Firm

Foreign Patent References

  • 0040590 EP. 05/13/1981
  • 1480811 EP. 01/13/1985
  • 0054010 EP. 02/13/1985
  • 0143764 EP. 06/13/1985
  • 0278174 EP. 08/13/1986
  • 0232690 EP. 08/13/1987
  • 0218174 EP. 12/13/1987
  • WO8300435 WO. 02/13/1983
  • 8603676 WO. 12/13/1985

International Classes

A61K 009/58
A61K 009/62
A61K 009/14
A61K 047/32

Foreign Application Priority Data

1989-11-22 SE

Abstract

An oral pharmaceutical composition is described for targeted slow release in the treatment of inflammatory bowel diseases. Also described are pharmaceutical compositions for peroral treatment targeted to different areas of the intestinal tract afflicted by ulcerative colitis and certain aspects of Crohn's disease.

Other References

  • Wolman et al., Scand. J. Gastroenterology, vol. 24, Suppl. 15, pp. 146-147 (1989)
  • Manufacturer's Info. (FMC Corporation) re: "Aquacoat" (ethyl-cellulose), 1987: Altering Drug Release Rates-Coating Methods
  • Manufacturer's Info. re: "Eudragit" (Apr. 1989), Lehmann, et al., Practical Course in Lacquer Coating and Survey of Course (Apr. 1989) relating to the use of Eudragit, pp. 1-167
  • Johansson et al., Eur. J. Respir. Dis., vol. 63, Suppl. 122, pp. 74-84, 1982
  • Manufacturer's Info. re: "Aquacoat" (ethylcellulose), pp. 17-36, 1985
  • H. Bechgaard "Critical factors influencing gastrointestinal absorption--what is the role of pellets?" Acta Pharmaceutic Tech 28 (1982) 149
  • Wolman "Use of Oral Budesonide in a Patient with Small Bowel Crohn's Diseae . . . " Scand. J. Gastroenterol. 24 (1989) pp. 146-147
  • Danielsson et al. "A controlled randomized trial of Budesonide 20. Prednisolone Retention Enemas . . . " Scand. J. Gastroenterol. 22 (1987) pp. 987-992
  • Levine et al. "Coating of Oral Beclomethasone Dipropionate Capsules with Cellulose Acetate Phthalate . . . " Gastroenterology 92 (1987) pp. 1037-1044
  • Richards et al. "Absorption of Delayed Release A Prednisolone in Ulcrative Colitis and Crohn's Disease", J. Pharm. Pharmacol. 37 (1985), pp. 757-758
  • Jewell "Corticosteroids for the Management of Ulcerative Colitis and Crohn's Disease" 18 (1989) pp. 21-34
  • Jamstedt et al. "Effect of Bethmethasone Treatment on Iodothyronimes and Thyroid Hormone-binding Proteins During Controlled Nutrition", Acta Endocrinologica 103 (1983) pp. 188-191
  • Malchow et al., "Therapie des Morbus Crohn" Deutsche Medizinische Wochenschrift 1090 (1984) pp. 1811-1816
  • Andersson et al., "In Vitro Biotransformation of Glucocorticoids in Liver and Skin Homogenate Fraction from Man, Rat and Hairless Mouse". J. Steroid Biochem. 16 (1982) pp. 787-795
  • Anders Gamstedt et al 1983 "Effect of betamethasone treatment . . . " Acta Endocrinology 103: 188-191
  • A. Kresznai et al. 1986 "Decreased number of steroid receptors . . . " Haematologia 19: 299-301
  • P. Thomas et al. 1985 "Absorption of delayed--release . . . " J. Pharmaceutical Pharmocology 37: 757
  • Kumana et al. 1982 "Beclomethasone dipropionate enemas . . . " Lancet 1 pp. 579-583 (Dialog
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