Protein- or peptide-cochleate vaccines and methods of immunizing using the same

Patent 5643574 Issued on July 1, 1997. Estimated Expiration Date:

July 1, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Large unilamellar vesicles (LUV) and method of preparing same
Patent #: 4078052
Issued on: 03/07/1978
Inventor: Papahadjopoulos

Liposome methods and compositions
Patent #: 4663161
Issued on: 05/05/1987
Inventor: Mannino , et al.

Reconstituting viral glycoproteins into large phospholipid vesicles Patent #: 4871488
Issued on: 10/03/1989
Inventor: Mannino , et al.

Inventors

Assignee

Application

No. 130986 filed on 10/04/1993

US Classes:

424/184.1, ANTIGEN, EPITOPE, OR OTHER IMMUNOSPECIFIC IMMUNOEFFECTOR (E.G., IMMUNOSPECIFIC VACCINE, IMMUNOSPECIFIC STIMULATOR OF CELL-MEDIATED IMMUNITY, IMMUNOSPECIFIC TOLEROGEN, IMMUNOSPECIFIC IMMUNOSUPPRESSOR, ETC.)264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)514/8Glycoprotein (carbohydrate containing)

Examiners

Primary: Housel, James C.
Assistant: Minnifield, N. M.

Attorney, Agent or Firm

Sughrue, Mion, Zinn, Macpeak & Seas

International Classes

A61K 039/00
A61K 051/00
A61K 038/16
B01J 013/02

Abstract

A method is described of immunizing a host by administering a biologically effective amount of a protein- or peptide-cochleate comprising at least a protein or peptide to which an immune response is elicited, a negatively charged lipid, and a divalent cation.

Other References

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