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High volume hyperpolarizer for spin-polarized noble gas

Patent 5642625 Issued on July 1, 1997. Estimated Expiration Date: Icon_subject March 29, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Apparatus and method for purification of gases used in exciplex (excimer) lasers
Patent #: 4977749
Issued on: 12/18/1990
Inventor: Sercel

Purification of laser gases Patent #: 5073896
Issued on: 12/17/1991
Inventor: Reid, et al.

Inventors

Assignee

Application

No. 622863 filed on 03/29/1996

US Classes:

62/55.5, LOW PRESSURE COLD TRAP PROCESS AND APPARATUS62/919, ISOTOPE62/925Xenon or krypton

Examiners

Primary: Capossela, Ronald C.

Attorney, Agent or Firm

International Class

B01D 008/00

Abstract

A method and apparatus for hyperpolarization of flowing noble gases is disclosed, including means for hyperpolarization of noble gases in a continuous flow arrangement. Noble gases such as xenon-129 and helium-3 can be hyperpolarized using the disclosed method and apparatus. Preferably, the noble gas is hyperpolarized via spin exchange between atoms of the noble gas and an alkali metal such as rubidium. Also, a method and apparatus for accumulation and/or storage of hyperpolarized noble gases in a continuous flow arrangement is provided. The method and apparatus enable large scale production, storage, and usage of hyperpolarized noble gases for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

Other References

  • Wagshul, et al., "Optical Pumping Of High-Density Rb With A Broadband Dye Laser And GaAl As Siode Laser Arrays: Application to 3 He Polarization", Physical Review A, vol. 40, No. 8, pp. 4447-4454 (1989)
  • Gatzke, et al., "Extraordinarily Slow Nuclear Spin Relaxation In Frozen Laser-Polarized 129 Xe", Physical Review Letters, vol. 50, No. 5, pp. 690-693 (1993)
  • Cates, et al., "Laser Production Of Large Nuclear-Spin Polarization In Frozen Xenon", Physical Review Letters, vol. 65, No. 20, pp. 2591-2594 (1990)
  • Becker, et al., "Study Of Mechanical Compression Of Spin-Polarized 3 He Gas", Nuclear Instruments And Methods In Physics Research, vol. A 346, pp. 45-51 (1994)
  • Middleton, et al., "MR Imaging With Hyperpolarized 3 He Gas", Magnetic Resonance In Medicine, vol. 33, pp. 271-275 (1995)
  • Cummings, et al., "Optical Pumping Of Rb Vapor Using High-Power Ga1 -x Alx As Diode Laser Arrays", Physical Review A, vol. 51, No. 6, pp. 4842-4851 (1995)
  • Middleton, "The Spin Structure Of The Neutron Determined Using A Polarized 3 He Target", Ph.D Dissertation, Princeton University (1994
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