Insect retinoid-like receptor compositions and methods
June 5, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesTrittum labelled compound, its preparation and its use in the determination of the affinity of retinoids for their cellular receptor Retinoic acid receptor method Compound marked with tritium, its preparation and its use in the location of nuclear receptors of retinoids Retinoic acid receptor composition Receptors: their identification, characterization, preparation and use Human gamma retinoic acid receptor DNA Receptors: their identification, characterization, preparation and use Retinoic acid receptor composition Receptors: their identification, characterization, preparation and use Hormone receptor compositions and methods InventorsApplicationNo. 464266 filed on 06/05/1995US Classes:435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide530/350PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUESExaminersPrimary: Zitomer, Stephanie W.Assistant: Atzel, Amy Attorney, Agent or FirmInternational ClassesC12P 021/06C12N 005/00 C07K 001/00 AbstractThe present invention relates to the discovery of novel insect receptor polypeptides, which, when complexed with certain ligands, or otherwise activated by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with the promoters of the genes. The novel receptors of the invention are substantially similar to previously discovered mammalian receptors which are activated to modulate transcription of certain genes in cells, when the cells are exposed to retinoic acid. The invention provides DNAs encoding the novel receptors, including expression vectors for expression of the receptors in cells; cells transformed with such expression vectors; cells co-transformed with such expression vectors and with reporter vectors to monitor activation of the receptors to modulate transcription, when the cells are exposed to ligand for the invention receptor; and methods of using such co-transformed cells in screening for compounds which are capable of leading to activation of the receptors and for compounds which are capable of interfering with such activation and, as such, are potentially potent insecticides. The invention also provides DNA and RNA probes for identifying DNA's encoding related receptors, of insects and other animals, of the class, to which the novel receptors of the invention belong.Other References
Field of SearchN-glycosides, polymers thereof, metal derivatives (e.g., nucleic acids, oligonucleotides, etc.)DNA or RNA fragments or modified forms thereof (e.g., genes, etc.) PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES Recombinant DNA technique included in method of making a protein or polypeptide Transformants (e.g., recombinant DNA or vector or foreign or exogenous gene containing, fused bacteria, etc.) Aspergillus |
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