U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method for removing unreacted electrophiles from a reaction mixture

Patent 5632898 Issued on May 27, 1997. Estimated Expiration Date: Icon_subject August 13, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventors

Assignee

Application

No. 696054 filed on 08/13/1996

US Classes:

210/656, Chromatography210/668, By chemically modifying or inhibiting dispersed constituent210/669, Prior to ion exchange or sorption210/681, Removing ions210/683, Anions210/692Utilizing synthetic resin

Examiners

Primary: Nessler, Cynthia L.

Attorney, Agent or Firm

International Class

C02F 001/42

Abstract

Simple and efficient methods for scavenging excess electrophiles from a reaction mixture are provided utilizing addition of water soluble nucleophiles or solid support bound nucleophiles. Resulting addition products are removed from reaction mixtures through convenient separation techniques.

Other References

  • Lowry T.H. and Richardson K.S. "Mechanism and Theory in Organic Chemistry", Third Edition; Harper Collins Publishers, pp. 367-373, 1987
  • Curran D.P. and Hadida S. "Tris(2(perfluorohexyl)ethyl)tin Hydride: A New Fluorous Reagent for Use in Traditional Organic Synthesis and Liquid Phase Combinatorial Synthesis", J. Am. Chem. Soc., 118:2531-2532, 1996
  • Curran D.P. and Hoshino M. "Stille Couplings with Fluorous Tin Reactants: Attractive Features for Preparative Organic Synthesis and Liquid-Phase Combinatorial Synthesis", J. Org. Chem., 61:6480-6481, 1996
  • Curran D.P. "Combinatorial Organic Synthesis and Phase Separation: Back to the Future", Combinatorial Chemistry/ Chemtracts-Organic Chemistry, pp. 75-87, Mar./Apr. 199
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