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US Patent 5625458 - Method and system for imaging objects in turbid media using diffusive fermat photons

US Patent Issued on April 29, 1997
Estimated Patent Expiration Date: Icon_subject February 3, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A method for imaging objects in turbid media. According to one embodiment of the invention, the method comprises the steps of (a) illuminating the object through the turbid medium with a pulse of light, the light emergent from the turbid medium consisting of a ballistic component, a snake-like component and a diffusive component, the diffusive component including Fermat photons and non-Fermat photons; (b) gating the light emergent from the turbid medium to preferentially select Fermat photons; and (c) forming an image of the object using the gated light. Preferably, a spatial gate is used to preferentially select Fermat photons from the emergent light. This may be done by orienting the source of the illuminating light and a light detector to lie along a most favorable path travelled predominately by Fermat photons. A time gate, such as a streak camera or the like, may be used in addition to the spatial gate to more carefully select Fermat photons from the emergent light. The above-described method may also be used to produce a tomography map of a turbid medium for use in detecting an object located within the turbid medium. This may be done, for example, by providing two or more pairs of light sources and light detectors which are arranged to provide intersecting most favorable paths. The present invention is also directed to systems constructed in accordance with the foregoing methods.

Other References

  • Alfano et al., "Photons for prompt tumor detection," Physics World, pp. 37-40 (Jan. 1992)
  • Feynman et al., "Quantum Mechanics and Path Integrals," pp. 336-340, McGraw-Hill Book Company, New York (1965)
  • Yoo et al., "Time-resolved coherent and incoherent components of forward light scattering in random media," Optics Letters, 15(6):320-2 (Mar. 15, 1990)
  • Wang et al., "Ballistic 2-D Imaging Through Scattering Walls Using an Ultrafast Optical Kerr Gate," Science, 253:769-71 (Aug. 16, 1991)
  • Feng et al., "Monte Carlo Simulations of Photon Migration Path Distributions in Multiple Scattering Media," SPIE, 1888:78-89 (1993)
  • Perelman et al., "Photon Migration in Turbid Media Using Path Integrals," Physical Review Letters, 72(9):1341-4 (Feb. 28, 1994)
  • O'Leary et al., "Refractin of Diffuse Photon Density Waves," Physical Review Letters, 69(18):2658-61 (Nov. 2, 1992)
  • Yoo et al., "When Does the Diffusion Approximation Fail to Descirbe Photon Transport in Random Media," Physical Review Letters, 64(22):2647-50 (May 28, 1990)
  • Chen et al., "Two-dimensional imaging through diffusing media using 150-fs gated electronics holography techniques," Optics Letters, 16(7):487-9 (Apr. 1, 1991)
  • Hee et al., "Femtosecond transillumination tomography in thick tissues," Optics Letters, 18(13):1107-9 (Jul. 1, 1993)
  • Duncan et al., "Time-gated imaging through scattering media using stimulated Raman amplification," Optics Letters, 16(23):1868-70 (Dec. 1, 1991

Inventors

Application

No. 384112 filed on 02/03/1995

US Classes:

356/446With diffusion

Field of Search

356/334, With diffraction grating means356/337, BY PARTICLE LIGHT SCATTERING356/342, Of back-scattered light356/335, FOR SIZE OF PARTICLES356/338, With photocell detection356/336, By particle light scattering356/332, Having adjustable color or bandwidth356/339, At right angles to the light beam (e.g., nephelometer)356/340, At variable angle to the light beam356/333, In a double monochromator356/341, For light comparison means356/343, Using plural photocells356/446, With diffusion250/341.1, With irradiation or heating of object or material250/358.1, With means to inspect passive solid objects250/341.8Measuring infrared radiation reflected from sample

Examiners

Primary: Gonzalez, Frank
Assistant: Eisenberg, Jason D.

Attorney, Agent or Firm

US Patent References

4515165, Apparatus and method for detecting tumors
Issued on: 05/07/1985
Inventor: Carroll
5140463, Method and apparatus for improving the signal to noise ratio of an image formed of an object hidden in or behind a semi-opaque random media
Issued on: 08/18/1992
Inventor: Yoo, et al.
5142372, Three-dimensional optical imaging of semi-transparent and opaque objects using ultrashort light pulses, a streak camera and a coherent fiber bundle
Issued on: 08/25/1992
Inventor: Alfano, et al.
5203339, Method and apparatus for imaging a physical parameter in turbid media using diffuse waves
Issued on: 04/20/1993
Inventor: Knuttel, et al.
5227912, Multiple-stage optical Kerr gate system
Issued on: 07/13/1993
Inventor: Ho, et al.
5275168, Time-gated imaging through dense-scattering materials using stimulated Raman amplification
Issued on: 01/04/1994
Inventor: Reintjes, et al.
5299035, Holographic imaging through scattering media
Issued on: 03/29/1994
Inventor: Leith, et al.
5349951, Optical CT imaging device
Issued on: 09/27/1994
Inventor: Ito, et al.
5353799, Examination of subjects using photon migration with high directionality techniques
Issued on: 10/11/1994
Inventor: Chance
5369496, Noninvasive method and apparatus for characterizing biological materials
Issued on: 11/29/1994
Inventor: Alfano, et al.
5371368, Ultrafast optical imaging of objects in a scattering medium
Issued on: 12/06/1994
Inventor: Alfano, et al.
5416582, Method and apparatus for localization and spectroscopy of objects using optical frequency modulation of diffusion waves
Issued on: 05/16/1995
Inventor: Knutson, et al.
5418797Time gated imaging through scattering material using polarization and stimulated raman amplification
Issued on: 05/23/1995
Inventor: Bashkansky, et al.

International Classes

A61B 005/00
A61B 006/00

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