Synthetic pulmonary surfactant Patent #: 4861756
ApplicationNo. 502722 filed on 07/14/1995
US Classes:530/330, 4 to 5 amino acid residues in defined sequence530/331Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc.
ExaminersPrimary: Davenport, Avis M.
Attorney, Agent or Firm
Foreign Patent References
International ClassesA61K 038/00
AbstractSynthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide of 3-4 amino acid residues, with an antioxidant moiety, and a lipid consisting of one or more of the lipids associated with natural pulmonary surfactant were prepared. These surfactants are useful in the treatment of respiratory distress syndrome.
Field of Search4 to 5 amino acid residues in defined sequence
Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc.
Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.
5 or 6 peptide repeating units in known peptide chain
3 or 4 peptide repeating units in known peptide chain