Process and apparatus for making rapidly dissolving dosage units and product therefrom

Patent 5622719 Issued on April 22, 1997. Estimated Expiration Date:

May 23, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Application

No. 652252 filed on 05/23/1996

US Classes:

424/488, Polysaccharides (e.g., cellulose, etc.)424/439, Food or edible as carrier for pharmaceutical424/464, Tablets, lozenges, or pills424/466, Effervescent426/658, Carbohydrate containing514/777, Carbohydrate or lignin, or derivative514/819ANTACID, ORAL

Examiners

Primary: Hulina, Amy

Attorney, Agent or Firm

Hoffmann & Baron

Foreign Patent References

609135 AU. 04/13/1988
609137 AU. 04/13/1988
900605 BE. 11/13/1977
1303511 CA. 04/13/1988
0287488A1 EP. 03/13/1988
0387950A1 EP. 08/13/1990
86052 IL. 04/13/1988
86053 IL. 04/13/1988
88/2771 ZA. 04/13/1988
88/2770 ZA. 04/13/1988
89/9318 ZA. 12/13/1989
90/2139 ZA. 03/13/1990
90/8406 ZA. 08/13/1991
519858 CH. 05/13/1971
489211 CH. 07/13/1986
2155934 GB. 03/13/1985
WO91/18613 WO. 05/13/1991

International Classes

A61K 009/20
A61K 009/46

Abstract

The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.

Other References

R.H. Doremus, "Crystallization of Sucrose From Aqueous Solution," Journal of Colloid and Interface Science, 104, pp. 114-120 (1985)
P. Bennema, "Surface Diffusion and the Growth of Sucrose Crystals," Journal of Crystal Growth, 3,4 pp. 331-334 (1968)
T.D. Simpson, et al., "Crystalline Forms of Lactose Produced in Acidic Alcoholic Media," Journal of food Science, 47, pp. 1948-1954 (1982)
A.D. Randolph, et al., "Continuous Sucrose Nucleation," The International Sugar Journal, pp. 8-12 (1974)
K.B. Domovs, et al., "Methanol-Soluble Complexes of Lactose and of other Carbohydrates," J. Dairy Science, 43, pp. 1216-1223 (1960)
A.D. Randolph, et al., "Continuous Sucrose Nucleation," The International Sugar Journal, pp. 35-38 (1974)
A.D. Randolph, et al., "Continuous Sucrose Nucleation," The International Sugar Journal pp. 73-77 (1974)
ICI Americas Inc., "ICI Americas Products for Cosmetics and Pharmaceuticals," (1977)
Domino Sugar Corporation, "Co-crystallization"
Domino Sugar Corporation, "Raspberry"
Domino Sugar Corporation, "Molasses Dark