U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Immunoassay reagents

Patent 5618926 Issued on April 8, 1997. Estimated Expiration Date: Icon_subject May 26, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3888864

3917582

Aminophenyl esters of 5-carboxyalkyl barbituric acids
Patent #: 4101549
Issued on: 07/18/1978
Inventor: Focella ,   et al.

Immunoassay for phencyclidine
Patent #: 4196185
Issued on: 04/01/1980
Inventor: Focella ,   et al.

Specific binding assay method and reagent means
Patent #: 4205952
Issued on: 06/03/1980
Inventor: Cais

Amitriptyline conjugates to antigenic proteins and enzymes
Patent #: 4223013
Issued on: 09/16/1980
Inventor: Hu ,   et al.

Theophylline antigens and antibodies
Patent #: 4262089
Issued on: 04/14/1981
Inventor: Singh ,   et al.

Imipramine derivatives and poly(amino acid) conjugates
Patent #: 4275160
Issued on: 06/23/1981
Inventor: Singh ,   et al.

Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
Patent #: 4318846
Issued on: 03/09/1982
Inventor: Khanna ,   et al.

Diagnostic test for barbiturates
Patent #: 4340736
Issued on: 07/20/1982
Inventor: Focella ,   et al.

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Inventors

Assignee

Application

No. 249676 filed on 05/26/1994

US Classes:

530/403, Protein is identified as an antigen, e.g., immunogenic carriers, etc.436/533, Carrier is water suspendible particles (e.g., latex, etc.)436/815, TEST FOR NAMED COMPOUND OR CLASS OF COMPOUNDS436/816, Alkaloids, amphetamines, and barbiturates530/404, Sulfur containing reactant530/405, Nitrogen containing reactant530/807, HAPTEN CONJUGATED WITH PEPTIDE OR PROTEIN530/816Attached to the carrier via a bridging agent

Examiners

Primary: Ceperley, Mary E.

Attorney, Agent or Firm

Foreign Patent References

  • 045334 EP. 08/13/1980
  • 46004 EP. 02/13/1982
  • 073611 EP. 08/13/1982
  • 199042 EP. 03/13/1986
  • 296883 EP. 06/13/1988
  • 279308 EP. 08/13/1988

International Classes

C07K 017/06
G01N 033/547

Abstract

Novel reagents for the detection by immunoassay of drugs in body fluids, their preparation and use are disclosed. The reagents of the present invention correspond to the formulaP--[A--D]nwhere:D is a drug derivative suitably selective for the determination of the presence of the target drug or drug metabolite,A is an activating linker-spacer group having an N-hydroxysuccinimide or isothiocyanate derived linking moiety,P is a poly(amino acid) or polymer capable of covalently bonding with A, andn is less than l.

Other References

  • Erlanger, Methods in Enzymology, 70: 85-104 (1980)
  • Schwartz et al., J. Org. Chem., 51:5463-5465 (1986)
  • Earley et al., J. Med. Chem., 11:774-777 (1968)
  • M. Brinkley, Bioconjugate Chem., vol. 3, pp. 2-13 (1992
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