Patent 5618845 Issued on April 8, 1997. Estimated Expiration Date: October 6, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Pharmaceutical compositions comprising modafinil in the form of particles of defined size. The particle size of modafinil can have a significant effect on the potency and safety profile of the drug.
Other References
Remington's Pharmaceutical Sciences 16th Ed (1980) pp. 1355-1368, 305-306, 1535-1545
Carlson et al Clin. Ther. 15(5):788-796 (1993) Micronized Glyburide
Treffel et al Acta Derm. Venerol. 72(1):65-67 (1992) Micronized 5-Methoxypsoralen
Hargrove et al AM. J. Abstrt. Gynecol. 161(4):948-951 (1989) Micronized Progesterone
Stock et al Bor. J. Dermatol. 112(4):469-473 (1985) Micronized 5-Methoxypsorale
McInnes et al. J. Clin Pharmacol 22(8):410-417 Micronized Spironolactone
Lavharanta et al Arch. Dermatol. Res. 273(1/2) 111-114 (1982) Micronized 8-Methoxypsoralen
Bastuji H. et al.; "Successful Treatment of Idiopathic Hypersomnia and Narcolepsy with Modafinil"; Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 12:695-700 (1988)
Becue T. et al.; "Confirmation of the Structure of By-Products in the Synthesis of Modafinil by Liquid Chromatography-Mass Spectrometry"; J. Chromatography 557:489-494 (1991)
Drouin J.E. et al.; "Optimization of the Mobile Phase for the Liquid Chromatographic Separation of Modafinil Optical Isomers on a Chiral-AGP Column"; J. Chromatography 605:19-31 (1992)
Duteil J. et al.; "Central 1 -Adrenergic Stimulation in Relation to the Behavior Stimulating Effect of Modafinil; Studies with Experimental Animals"; European J. Pharmacol. 180:49-58 (1990)
Drugs of the Future; "Modafinil"; 15(2):130-132 (1990)
Fuxe K. et al.; "Evidence for a Protective Action of the Vigilance Promoting Drug Modafinil on the MPTP-Induced Degeneration of the Nigrostriatal Dopamine Neurons in . . . "; Exp. Brain Res. 88:117-130 (1992)
Lyons T.J. et al.; "Modafinil: The Unique Properties of a New Stimulant"; Aviation, Space & Environ. Med. 432-435 (1991)
Milhaud C. et al.; "Effects of Modafinil, An Alpha I Adrenergic Type Psychostimulant on the Sleep of Monkeys"; Psychopharmacology 96:Abstract No. 31.05.09 (1988)
Milhaud C.L. et al.; "Presentation of d'un Nouveau Stimulant:Le CRL-40476"; AGARD Conf. Proc. 415:5-1-5-7 (1987)
Moachon G. et al.; "Simultaneous Determination of Modafinil and its Acid Metabolite by High-Performance Liquid Chromatography in Human Plasma"; J. Chromatography B 654:91-96 (1994)
Roze C. et al.; "Drug CRL 40 028-Induced Inhibition of Pancreatic Secretion in Rats"; Arch Int Pharmacodyn 265:119-127 (1983)
Saletu B. et al.; "Differential Effects of a New Central Adrenergic Agonist-Modafinil-and D-Amphetamine on Sleep and Early Morning Behaviour in Young Healthy Volunteers"; Int J Clin Pharm Res IX(3):183-195 (1989
October 6, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
