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Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures

Patent 5617859 Issued on April 8, 1997. Estimated Expiration Date: Icon_subject October 2, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Altered dipole moment magnetic resonance imaging method
Patent #: 5357959
Issued on: 10/25/1994
Inventor: Fishman

Magnetic resonance (MR) angiography in a low-field imaging magnet Patent #: 5479925
Issued on: 01/02/1996
Inventor: Dumoulin, et al.

Inventors

Application

No. 537574 filed on 10/02/1995

US Classes:

600/420, Using detectable material placed in body324/309, To obtain localized resonance within a sample600/422Coil

Examiners

Primary: Lateef, Marvin M.
Assistant: Shaw, Shawna J.

Attorney, Agent or Firm

International Class

A61B 005/055

Abstract

A magnetic resonance (MR) active invasive device system employs a small, high-field polarizing magnet, and a large magnetic resonance (MR) imaging magnet for the purpose of generating MR images of selected body cavities. A subject is positioned in a large low-field MR imaging magnet. A substance, intended to be used as a contrast agent is first cooled, and then passed through the small high-field polarizing magnet where it becomes highly polarized. The substance is then heated to physiologic temperatures, vaporized, and introduced into the subject through a transfer conduit as a vapor. Radiofrequency (RF) pulses and magnetic field gradients are then applied to the patient as in conventional MR imaging. Since the vapor is highly polarized, it can be imaged even though it has a much lower density than the surrounding tissue.

Other References

  • "MRI Using Hyperpolarized Gas" By G.A. Johnson, R.D. Black, G. Cates, G. Cofer, R. Gunther, W. Happer, L.W. Hedlund, H. Middleton & J. Swartz, Proceedings of the Society of Magnetic Resonance and the European Society for Magnetic Resonance in Medicine and Biology, Nice, France, Aug. 19-25, 1995, vol. 1 pp. 39
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