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US Patent 5616345 - Controlled absorption diltiazen formulation for once-daily administration
US Patent Issued on April 1, 1997
Estimated Patent Expiration Date:
November 4, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
November 4, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractA diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of the diltiazem from the pellet at a rate allowing controlled absorption thereof over a twenty four hour period following oral administration.Other References
| InventorsAssigneeApplicationNo. 334864 filed on 11/04/1994US Classes:424/497, Containing solid synthetic polymers424/457, Sustained or differential release424/458, Containing discrete coated particles pellets, granules, or beads424/459, Organic coatings424/462, Containing solid synthetic polymers424/468, Sustained or differential release type424/490Coated (e.g., microcapsules)Field of Search424/497, Containing solid synthetic polymers424/462, Containing solid synthetic polymers424/468, Sustained or differential release type424/490Coated (e.g., microcapsules)ExaminersPrimary: Phelan, D. GabrielleAttorney, Agent or FirmUS Patent References2853420, 4443497, Method of preparing microcapsulesIssued on: 04/17/1984 Inventor: Samejima , et al.4459279, Retard form of pharmaceuticals with insoluble porous diffusion coatings Issued on: 07/10/1984 Inventor: Stricker , et al.4462982, Microcapsules and method of preparing same Issued on: 07/31/1984 Inventor: Samejima , et al.4555398, Sustained-release vasodilator Issued on: 11/26/1985 Inventor: Oda4587242, Sulfonic resins having a therapeutical activity, preparation thereof and pharmaceutical compositions containing them Issued on: 05/06/1986 Inventor: Manghisi , et al.4608248, Process for time-controlled release of active ingredients Issued on: 08/26/1986 Inventor: Knecht , et al.4721619, Controlled absorption diltiazen pharmaceutical formulation Issued on: 01/26/1988 Inventor: Panoz , et al.4786503, Dosage form comprising parallel lamine Issued on: 11/22/1988 Inventor: Edgren , et al.4792452, Controlled release formulation Issued on: 12/20/1988 Inventor: Howard , et al.4795642, Gelatin-encapsulated controlled-release composition Issued on: 01/03/1989 Inventor: Cohen , et al.4795644, Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins Issued on: 01/03/1989 Inventor: Zentner4814183, Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins Issued on: 03/21/1989 Inventor: Zentner4894240Controlled absorption diltiazem formulation for once-daily administration Issued on: 01/16/1990 Inventor: Geoghegan, et al. Foreign Patent References
International ClassA61K 009/16Foreign Application Priority Data1983-12-22 IE |
