Controlled absorption diltiazen formulation for once-daily administration
November 4, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2853420 Method of preparing microcapsules Retard form of pharmaceuticals with insoluble porous diffusion coatings Microcapsules and method of preparing same Sustained-release vasodilator Sulfonic resins having a therapeutical activity, preparation thereof and pharmaceutical compositions containing them Process for time-controlled release of active ingredients Controlled absorption diltiazen pharmaceutical formulation Dosage form comprising parallel lamine Controlled release formulation InventorsAssigneeApplicationNo. 334864 filed on 11/04/1994US Classes:424/497, Containing solid synthetic polymers424/457, Sustained or differential release424/458, Containing discrete coated particles pellets, granules, or beads424/459, Organic coatings424/462, Containing solid synthetic polymers424/468, Sustained or differential release type424/490Coated (e.g., microcapsules)ExaminersPrimary: Phelan, D. GabrielleAttorney, Agent or FirmForeign Patent References
International ClassA61K 009/16Foreign Application Priority Data1983-12-22 IEAbstractA diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of the diltiazem from the pellet at a rate allowing controlled absorption thereof over a twenty four hour period following oral administration.Other References
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